Public Release:  JCI online ahead of print table of contents for March 3, 2014

Journal of Clinical Investigation

Identification of factors that influence breast cancer metastasis to bone

One of the more serious and frequent complications of advanced breast cancer is bone metastasis, which is exacerbated by TGF-β signaling; however, it is not clear how TGF-β production is regulated prior to and during metastasis. In this issue of the Journal of Clinical Investigation, Guohong Hu and colleagues at the Shanghai Institutes for Biological Sciences evaluated murine models of invasive breast cancer and determined that cancer cells lacking the putative tumor suppressor DLC1 have a greater propensity toward infiltrating bone, while overexpression of DLC1 inhibited bone colonization. DLC1 knockdown increased TGF-β signaling, resulting in elevated levels of parathyroid hormone-like hormone (PTHLH) and increased metastasis, and pharmacological inhibition of PTHLH production prevented spread to bone. Furthermore, evaluation of clinical breast tumor samples revealed a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.

TITLE: DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, , CHN
Phone: 86-21-63844516; E-mail:

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TITLE: Assembly of the cochlear gap junction macromolecular complex requires connexin 26

AUTHOR CONTACT: Kazusaku Kamiya
Juntendo University Faculty of Medicine, Tokyo, JPN
Phone: +81-3-5802-1229; Fax; E-mail:

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TITLE: Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis

Stowers Institute for Medical Research, Kansas City, MO, USA
Phone: 816-926-4414; E-mail:

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TITLE: SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

AUTHOR CONTACT: Guido Marcucci
The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
Phone: 614-366-2261; E-mail:

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TITLE: SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

Dana Farber Cancer Institute, Boston, MA, USA
Phone: 6176322477; E-mail:

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TITLE: Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis

AUTHOR CONTACT: Erwin Bottinger
Icahn School of Medicine at Mount Sinai, New York, NY, USA
Phone: 212.241.0800; Fax: 212.849.2643 ; E-mail:

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TITLE: Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

AUTHOR CONTACT: Thomas Gillingwater
University of Edinburgh, Edinburgh, UNK, GBR
Phone: +44 131 6503724; E-mail:

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TITLE: Fibrotic extracellular matrix activates a pro-fibrotic positive feedback loop

AUTHOR CONTACT: Matthew Parker
University of Minnesota, Minneapolis, USA
Phone: 612-205-2514; E-mail:

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