Alteration of the autophagic process is involved in neurodegeneration. The beclin 1 complex is shown to play a key role in the initial stage of autophagy. Dr. Yanming Wei and co-coworkers from College of Life Science, Northwest Agriculture & Forestry University in China pointed out the amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant can upregulate autophagic activity in NSC34 cells, but that this does not markedly affect beclin 1 complex components. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 1, 2014).
Article: " Autophagic induction of amyotrophic lateral sclerosislinked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells," by Yanming Wei (College of Life Science, Northwest Agriculture & Forestry University, Yangling 712100, Shaanxi Province, China)
Wei YM. Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells. Neural Regen Res. 2014;9(1):16-24.
Neural Regeneration Research
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.