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PUBLIC RELEASE DATE:
12-Mar-2014

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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research

PD-L1: A potential treatment target for multiple sclerosis

IMAGE: Immunohistochemical staining showed that PD-L1 immunoreactivity (brown) was present in infiltrating inflammatory cells around blood vessels in the spinal cord of experimental allergic encephalomyelitis mice.

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Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. Therefore, Qun Xue, Fanli Dong and co-workers from the First Affiliated Hospital of Soochow University in China speculated that programmed cell death 1 ligand 1 (PD-L1) plays an important role in the pathogenesis of multiple sclerosis. A recent study by these researchers published in the Neural Regeneration Research (Vol. 8, No. 35, 2013) found that the expression of PD-L1 in the spinal cord and splenocytes of mice with experimental allergic encephalomyelitis was significantly increased compared with normal mice. This evidence provides the basement for exploring the role of PD-L1 in multiple sclerosis.

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Article: " PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis " by Min Li1, Jiandong Jiang1, Bing Fu1, Jiechun Chen1, Qun Xue2, 3, Wanli Dong2, 3, Yanzheng Gu3, Lingtao Tang4, Limin Xue2, Qi Fang2, Mingyuan Wang5, Xueguang Zhang3 (1 Department of Neurology, Second People's Hospital of Lianyungang City, Lianyungang 222006, Jiangsu Province, China; 2 Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China; 3 Institute of Clinical Immunology, Soochow University, Suzhou 215006, Jiangsu Province, China; 4 Department of Neurology, Third Hospital of Xingtai City, Xingtai 054000, Hebei Province, China; 5 Red-Cross Blood Center of Suzhou City, Suzhou 215006, Jiangsu Province, China)

Li M, Jiang JD, Fu B, Chen JC, Xue Q, Dong WL, Gu YZ, Tang LT, Xue LM, Fang Q, Wang MY, Zhang XG. PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis. Neural Regen Res. 2013;8(35):3296-3305.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/



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