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5-Mar-2014

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Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
@WKHealth

Prehospital alerts let stroke patients skip the emergency room

Going directly for CT scans can shorten the time to emergency treatment, says study in Neurosurgery

Philadelphia, Pa. (March 4, 2014) - Prehospital stroke alerts by emergency medical services (EMS) personnel can shorten the time to effective treatment with "clot-busting" drugs for patients with stroke, according to a report in the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Dr. Mandy J. Binning and colleagues at the Capital Institute for Neurosciences (CIN) at Capital Health, Trenton and Pennington, N.J., implemented a prehospital stroke alert (PHSA) protocol in a specialized neurological emergency department (ED) setting. The PHSA approach allows patients with probable stroke to bypass the ED and go for immediate computed tomography (CT) scanning--saving valuable minutes in emergency treatment of stroke.

Trained EMS Personnel Issue Prehospital Stroke Alerts...

The PHSA system was introduced at Capital Health's two neurological EDs to facilitate emergency treatment with tissue plasminogen activator (tPA). Intravenous tPA can dissolve the clot that's causing the stroke. However, to be effective, treatment must be started within 4.5 hours after initial stroke symptoms. Ideally, the "door-to-needle" time--from arrival at the hospital to the start of tPA treatment--should be less than one hour.

In the PHSA approach, specialists at the CIN gave EMS personnel special training in identifying stroke patients. After training, the EMS personnel could send a prenotification to the hospital, letting the ED team know that a patient with possible stroke was on the way.

After issuing a PHSA, the EMS personnel brought the patient directly to the CT suite, bypassing the usual ED routines. They were met by the neurological emergency team, which performed a quick assessment and CT scan of the brain. If stroke was confirmed in the appropriate time frame, tPA treatment was started immediately.

The new study reports on 141 patients with prehospital stroke alerts who were stable enough to bypass the ED and go directly to CT. The EMS personnel made an accurate assessment of stroke in two thirds of patients, and correctly identified patients with neurological conditions nearly 90 percent of the time.

...Saving Valuable Time to Emergency Stroke Treatment

On average, CT scans were performed about 12 minutes after the patient arrived at the hospital--compared to 35 minutes before the PHSA system was introduced.

The median door-to-needle time was 57 minutes, compared to 99 minutes before the PHSA system. The overall percentage of stroke patients receiving tPA was 18 percent, compared to an average of five percent over the previous three years.

Despite the documented benefits of clot-dissolving drugs for patients with stroke and recommendations for rapid treatment, only a small percentage of stroke patients actually receive tPA. Hospital prenotification by EMS providers has been recommended to speed ED evaluation of patients with possible stroke. The new study shows that combining PHSAs with treatment at a specialized neurological ED can shorten the time to CT scanning and, when appropriate, tPA treatment in patients with stroke.

Dr. Binning and colleagues note that door-to-needle times have continued to decrease since the introduction of the PHSA protocol. They also report that they're seeing increased numbers of stroke patients--likely because EMS personnel are preferentially transporting patients with probable stroke to the neurological EDs, where they can receive specialized stroke care.

The improvements in door-to-CT and door-to-needle times "suggest that we are triaging and treating patients with acute neurological and neurosurgical emergencies more quickly," Dr. Binning and coauthors write. They are planning further studies to compare clinical outcomes in stroke patients treated before and after introduction of the PHSA protocol.

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About Neurosurgery

Neurosurgery, the Official Journal of the Congress of Neurological Surgeons, is your most complete window to the contemporary field of neurosurgery. Members of the Congress and non-member subscribers receive 3,000 pages per year packed with the very latest science, technology, and medicine, not to mention full-text online access to the world's most complete, up-to-the-minute neurosurgery resource. For professionals aware of the rapid pace of developments in the field, Neurosurgery is nothing short of indispensable.

About Wolters Kluwer Health

Wolters Kluwer Health is a leading global provider of information, business intelligence and point-of-care solutions for the healthcare industry. Serving more than 150 countries and territories worldwide, Wolters Kluwer Health's customers include professionals, institutions and students in medicine, nursing, allied health and pharmacy. Major brands include Health Language®, Lexicomp®, Lippincott Williams & Wilkins, Medicom®, Medknow, Ovid®, Pharmacy OneSource®, ProVation® Medical and UpToDate®.

Wolters Kluwer Health is part of Wolters Kluwer, a market-leading global information services company. Wolters Kluwer had 2012 annual revenues of €3.6 billion ($4.6 billion), employs approximately 19,000 people worldwide, and maintains operations in over 40 countries across Europe, North America, Asia Pacific, and Latin America. Follow our official Twitter handle: @WKHealth.



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