Public Release:  JCI online ahead of print table of contents for April 8, 2014

Journal of Clinical Investigation

Visualizing calcium dynamics in the kidney

In this issue of the Journal of Clinical Investigation, Janos Peti-Peterdi and colleagues at the University of Southern California used multiphoton microscopy (MPM) to directly visualize podocyte calcium dynamics within the intact kidneys of live mice. A robust calcium wave was generated in response to glomerular injury and this signal spread throughout cells. Mice lacking the P2Y2 purinergic receptor or treated with inhibitors of calcium signaling prevented propagation of a calcium wave. Furthermore, increased calcium signaling correlated with loss of glomerular filter integrity. Together this results suggest that calcium signaling mediates pathogenic responses to injury in the kidney.

TITLE: Intravital imaging of podocyte calcium in glomerular injury and disease

AUTHOR CONTACT: Janos Peti-Peterdi University of Southern California, Los Angeles, CA, USA Phone: 323-442-4337; E-mail: petipete@usc.edu

View this article at: http://www.jci.org/articles/view/71702


Characterization of an asplenic patient with disorder of sexual development

Mutations with in the gene encoding the transcription factor steroidogenic factor 1 (SF-1) are associated with disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. In this issue of the Journal of Clinical Investigation, David Zangen and colleagues at Hadassah Hebrew University Medical Centre identified a recessive mutation within SF1 that resulted in both severe 46,XY-DSD and asplenia in a pediatric patient. Interestingly, this particular SFI mutation decreased transactivation of TLX1, a transcription factor essential for murine spleen development. Additionally, the SF1 mutation decreased expression of steroidogenic genes, without affecting synergistic SF-1 and sex-determining region Y (SRY) coactivation of the testis development gene SOX9. This study indicates that SF-1 is required for both steroidogenesis and spleen development in humans.

TITLE: Testicular differentiation factor SF-1 is required for human spleen development

AUTHOR CONTACT: David Zangen Hadassah Hebrew University Medical Centre, Jerusalem, ISR Phone: 972.2.5844430; E-mail: zangend@hadassah.org.il

View this article at: http://www.jci.org/articles/view/73186


ENDOCRINOLOGY

TITLE: Vascular rarefaction mediates whitening of brown fat in obesity

AUTHOR CONTACT: Kenneth Walsh Boston University School of Medicine, Boston, MA, USA Phone: 617-414-2392; Fax: 617-414-2391; E-mail: kxwalsh@bu.edu

View this article at: http://www.jci.org/articles/view/71643

TITLE: Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

AUTHOR CONTACT: Antonio Zorzano Institute for Research in Biomedicine (IRB Barcelona), Barcelona, ESP Phone: 34-93-403-7197;; E-mail: antonio.zorzano@irbbarcelona.org

View this article at: http://www.jci.org/articles/view/72327

IMMUNOLOGY

TITLE: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis

AUTHOR CONTACT: Nathan Karin Department of Immunology, Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, ISR Phone: 972.4.8295232; E-mail: nkarin10@gmail.com

View this article at: http://www.jci.org/articles/view/71951

ONCOLOGY

TITLE: Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC

AUTHOR CONTACT: Jin Chen Vanderbilt University School of Medicine, Nashville, TN, USA Phone: 615-343-3819; Fax: 615-343-8648; E-mail: jin.chen@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/72522

HEPATOLOGY

TITLE: Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway

AUTHOR CONTACT: Anthony N. Hollenberg Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA Phone: 617.735.3268; E-mail: thollenb@bidmc.harvard.edu

View this article at: http://www.jci.org/articles/view/73419

###

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.