Public Release:  Atorvastatin protects against cerebral ischemia/reperfusion injury

Neural Regeneration Research

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IMAGE: Atorvastatin pretreatment significantly increased E-selectin (arrow) expression in the cortex of rats with cerebral ischemia/reperfusion (× 400). Diffusion tensor imaging showed that lesions were reduced and fractional anisotropy values decreased in... view more

Credit: Neural Regeneration Research

In addition to its lipid-lowering effect, statins exert anti-inflammatory and antioxidant effects as well. Statins also provide protection against renal, pulmonary and myocardial ischemia/reperfusion injury. However, little evidence is available on similar changes in cerebral ischemia/reperfusion injury. Therefore, Dr. Qiuyun Tu and colleagues from Third Xiangya Hospital of Central South University in China verified that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury through anti-infammatory and antioxidant effects. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).

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Article: " Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects " by Qiuyun Tu1, Hui Cao2, Wei Zhong 2, Binrong Ding1, Xiangqi Tang1 (1 Departments of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2 Departments of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China)

Tu QY, Cao H, Zhong W, Ding BR, Tang XQ. Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. Neural Regen Res. 2014;9(3):268-275.

Contact:

Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/

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