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PUBLIC RELEASE DATE:
2-Apr-2014

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Contact: Chew Munkit
mkchew@wspc.com.sg
656-466-5775
World Scientific
@worldscientific

Enhancing the immune response through next generation polymeric vaccine adjuvants

IMAGE: The easily modifiable properties of polymers and their potential for functionalization, shown in blue and red respectively, make them attractive candidates for replacing conventional adjuvants.

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The great success of vaccines over the past two centuries as a preventive medicine has led to a significant reduction in morbidity and death caused by controllable infectious diseases. The effectiveness of vaccines is dependent on their ability to induce a protective immune response in recipients. Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to patho-gens. Adjuvants are especially necessary to boost the immune response for subunit vac-cines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic. In addition to a comprehensive study of their use in vaccines, this article sum-marizes the benefits and challenges associated with the use of these polymer systems as adjuvants.

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This research was supported funding from the U.S. Army (Grant #W81XWH-10-1-0806). Corresponding author for this study in TECHNOLOGY is Surya Mallapragada, suryakm@iastate.edu

For the paper, please visit http://www.worldscientific.com/doi/pdf/10.1142/S2339547814300017

About TECHNOLOGY

Fashioned as a high-impact, high-visibility, top-echelon publication, this new ground-breaking journal - TECHNOLOGY - will feature the development of cutting-edge new technologies in a broad array of emerging fields of science and engineering. The content will have an applied science and technological slant with a focus on both innovation and application to daily lives. It will cover diverse disciplines such as health and life science, energy and environment, advanced materials, technology-based manufacturing, information science and technology, and marine and transportations technologies.

About World Scientific Publishing Co.

World Scientific Publishing is a leading independent publisher of books and journals for the scholarly, research and professional communities. The company publishes about 500 books annually and more than 120 journals in various fields. World Scientific collaborates with prestigious organisations like the Nobel Foundation, US National Academies Press, as well as its subsidiary, the Imperial College Press, amongst others, to bring high quality academic and professional content to researchers and academics worldwide. To find out more about World Scientific, please visit http://www.worldscientific.com.



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