National coordination needed to advance convergent research

WASHINGTON -- Convergent research – which crosses disciplinary boundaries, integrating tools and knowledge from the life sciences, physical sciences, engineering, and other fields -- could spur innovation and help tackle societal challenges, but greater national coordination is needed, says a new report from the National Research Council. Convergent science still faces hurdles and requires a culture shift for research institutions, which have traditionally organized research around separate disciplines.

Convergent science also relies on forming a web of partnerships to support boundary-crossing research and to translate advances into new products. The report identifies steps institutions and the nation can take to support these partnerships.

"Some of our most difficult real-world problems do not respect disciplinary boundaries, and convergent science, which brings together insights and approaches from many fields, can help us find solutions," said committee chair Joseph DeSimone, Chancellor's Eminent Professor of Chemistry at the University of North Carolina at Chapel Hill and the William R. Kenan Jr. Distinguished Professor of Chemical Engineering at NC State. "It is time for a systematic effort to highlight the value of convergence as an approach to R&D, and to address lingering challenges to its effective practice."

The report identifies areas where convergent approaches could accelerate innovation and help meet broad challenges, including creating new fuels and energy storage systems, meeting the world's need for secure food supplies in a changing climate, and developing new treatments for chronic illnesses.

Convergent research is already contributing to breakthroughs, the report notes. For example, convergence between the engineering and biotechnology worlds is bringing 3-D printing -- which enables custom objects to be built on demand within hours – to medicine, allowing the construction of medical implants customized to individual patients. Researchers are now working to develop 3-D printers that use living cells to construct human tissues and organs for transplants. Doing so will require integrating knowledge from life sciences on how to sustain cells through the printing process, from materials science on scaffolding to support the cells, and from engineering to design and construct the printing devices. Bringing these advances to doctors and patients will require partnerships with industrial, clinical, and regulatory colleagues.

But barriers to convergent science remain, and institutions often have little guidance on how to establish effective programs. The report identifies strategies used by institutions to support convergence efforts, such as creating research institutes or programs around a common theme, problem, or scientific challenge; hiring faculty in transdisciplinary clusters; and embedding support for convergence in the promotion and tenure process. Convergence efforts can also be informed by economic, social, and behavioral science and humanities research on establishing interdisciplinary cultures, supporting team-based science, and revising STEM education and training.

To accelerate convergence, experts, funding agencies, foundations, and other partners should identify key problems whose solution requires convergence approaches, the report recommends. Research institutions, funding agencies, foundations, and other partners should address barriers to convergence as they arise, and they should expand mechanisms for funding convergence efforts. Seed funding to catalyze collaborations should be implemented or expanded. Leaders and practitioners who have fostered a convergence culture in their organizations and laboratories should develop partnerships with other institutions, helping to nurture their convergence efforts.

To most effectively achieve such goals and move beyond the current patchwork of convergence efforts, greater coordination will be needed, the report says. National coordination on convergence would provide a platform for agencies that support biomedical research, such as the National Institutes of Health, and those that support research in the physical sciences, such as the National Science Foundation and the U.S. Department of Energy, to identify opportunities for collaboration. The power of such cross-agency efforts is illustrated by the success of the Human Genome Project, a collaborative effort of NIH and DOE.

Many stakeholders can be involved in the national coordination needed to advance convergence, the report says. For example, associations and societies can undertake convening efforts to set goals. Foundations could serve catalytic roles for the community. Cross-agency working groups could coordinate policy development. All of these actors can play vision-setting roles in establishing new strategies to facilitate convergence.

The study was sponsored by the Raymond and Beverley Sackler Science Fund of the National Academy of Sciences; the Burroughs Wellcome Fund; Kavli Foundation; Research Corporation for Science Advancement; National Science Foundation, National Institutes of Health; William R. Kenan, Jr. Institute for Engineering, Technology, and Science of North Carolina State University; Frank Hawkins Kenan Institute of Private Enterprise of the University of North Carolina at Chapel Hill; and the Connecticut Institute for Clinical and Translational Science at the University of Connecticut.

The National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council make up the National Academies. They are private, independent nonprofit institutions that provide science, technology, and health policy advice under a congressional charter granted to NAS in 1863. The National Research Council is the principal operating arm of the National Academy of Sciences and the National Academy of Engineering. For more information, visit http://national-academies.org. A committee roster follows.

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Joseph M. DeSimone1,2 (chair)
William R. Kenan Jr. Distinguished Professor of Chemical Engineering
North Carolina State University; and
Director, Frank Hawkins Kenan Institute of Private Enterprise, and
Chancellor's Eminent Professor of Chemistry
University of North Carolina
Chapel Hill

Timothy Galitski
Affiliate Professor
Institute for Systems Biology; and
Head of Science and Technology
EMD Millipore Corp.
Seattle

James M. Gentile
Dean for the Natural and Applied Sciences
Hope College
Holland, Mich.

Sharon C. Glotzer
S.W. Churchill Collegiate Professor of Chemical Engineering,
Professor of Materials Science and Engineering, and
Professor of Physics, Applied Physics, and Macromolecular Science and Engineering
University of Michigan
Ann Arbor

Susan M. Hockfield
President Emeritus and Professor of Neuroscience
Massachusetts Institute of Technology
Cambridge

Julie Thompson Klein
Professor of Humanities
English Department, and
Faculty Fellow for Interdisciplinary Development
Wayne State University
Ypsilanti, Mich.

Cato T. Laurencin2,3
Director, Institute for Regenerative Engineering,
Chief Executive Officer, Connecticut Institute for Clinical and Translational Science,
Van Dusen Chair in Academic Medicine, and
Distinguished Professor of Orthopaedic Surgery and Chemical, Materials, and Biomolecular Engineering,
UConn Health Center
Farmington

Cherry A. Murray1,2
Dean
School of Engineering and Applied Sciences
Harvard University
Cambridge, Mass.

Monica Olvera de la Cruz1
Director, Materials Research Center, and
Lawyer Taylor Professor of Materials Science and Engineering, Chemistry, and (by courtesy) Chemical and Biological Engineering
Northwestern University
Evanston, Ill.

Nicholas A. Peppas2,3
Fletcher Stuckey Pratt Chair in Engineering
Department of Biomedical Engineering, and
Professor
Departments of Chemical Engineering and Biomedical Engineering and College of Pharmacy
University of Texas
Austin

Lynne J. Regan
Professor of Molecular Biophysics and Biochemistry,
Professor of Chemistry, and
Director, Integrated Graduate Program in Physical and Engineering Biology
Yale University
New Haven, Conn.

J. David Roessner
Senior Fellow
Center for Science, Technology, and Economic Development
SRI International
Redwood City, Calif.

Katherine Bowman
Study Director

1 Member, National Academy of Sciences
2 Member, National Academy of Engineering
3 Member, Institute of Medicine