Diffuse lesions involving the posterior quadrant (PQ) of the cerebral hemisphere (temporal, parietal, and occipital lobes) induce intractable epilepsy. These patients are potential candidates for surgical treatment. Maintenance of isolated nerve tissue activity after surgery plays a crucial role in the neuroprotective effects of neurosurgery treatment. Shaoya Yin and colleagues from Tianjin Huanhu Hospital in China selected two patients with temporal-parietal-occipital (PTO) intractable epilepsy to receive posterior quadrant disconnection. Postoperative MRI scans of the two epileptic patients showed that the disconnected brain tissue still survived, the activity of temporal-parietal occipital nerve tissue was maintained, and nerve fibers were completely disconnected. The involved patients were followed-up for over 1 year after surgery, during which time the epilepsy was completely controlled. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 4, 2014).
Article: " Posterior quadrantic disconnection maintains the activity of isolated temporal-parietal-occipital nerve tissue: neuroprotective measures in the surgical treatment of epilepsy" by Shaoya Yin1, Keke Feng1, Mei Feng2, Xueqing Zhang2, Yuqin Zhang3 (1 Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, China; 2 Department of Electroneurophysiology, Tianjin Huanhu Hospital, Tianjin 300060, China; 3 Department of Pediatric Neurology, Tianjin Children's Hospital, Tianjin 300060, China) Yin SY, Feng KK, Feng M, Zhang XQ, Zhang YQ. Posterior quadrantic disconnection maintains the activity of isolated temporal-parietal-occipital nerve tissue: neuroprotective measures in the surgical treatment of epilepsy. Neural Regen Res. 2014;9(4):447-448.
Neural Regeneration Research
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