A recent study reported by Haigang Chang and co-workers from the First Affiliated Hospital of Xinxiang Medical University in China verified the effects of transient axonal glycoprotein-1 (TAG-1) on cell viability and p53, epidermal growth factor receptor (EGFR), and amyloid precursor protein (APP) intracellular C-terminal domain (AICD) expression in U251 glioma cells. Their pilot study showed that the signaling pathways induced by TAG-1, TAG-1/APP/AICD/p53 and TAG-1/APP/AICD/EGFR, did not inhibit glioma development by inhibiting cell proliferation or by inducing apoptosis. Instead, these signaling pathways enhanced proliferation. These findings, which were published in the Neural Regeneration Research (Vol. 9, No. 5, 2014), provide novel insight into the mechanisms of glial tumorigenesis.
Article: " Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells," by Haigang Chang1, 2, Shanshan Song3, Zhongcan Chen2, Yaxiao Wang1, Lujun Yang2, Mouxuan Du2, Yiquan Ke2, Ruxiang Xu4, Baozhe Jin1, Xiaodan Jiang2 (1 Department of Neurosurgery, the First Affliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China; 2 Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong Province, Department of Neurosurgery, Zhu-jiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China; 3 Eight-year Programme, the First Clinical Medical College of Southern Medical University, Guangzhou, Guangdong Province, China; 4 Department of Neurosurgery, Military General Hospital of Beijing PLA, Beijing, China)
Chang HG, Song SS, Chen ZC, Wang YX, Yang LJ, Du MX, Ke YQ, Xu RX, Jin BZ, Jiang XD. Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regen Res. 2014;9(5):519-525.