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PUBLIC RELEASE DATE:
16-Jun-2014

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Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
The JAMA Network Journals

Major surgery associated with increased risk of death or impairment in very-low-birth-weight infants

Bottom Line: Very-low-birth-weight (VLBW) babies who undergo major surgery appear to have an increased risk of death or subsequent neurodevelopmental impairment (NDI).

Author: Frank H. Morriss, Jr., M.D., M.P.H., of the University of Iowa, Iowa City, and colleagues.

Background: Some animal studies suggest general anesthesia for surgery can increase the risk for neurocognitive or behavioral deficits. This has raised some concerns about exposing infants to general anesthesia for surgery.

How the Study Was Conducted: The authors examined the association between very-low-birth-weight infants who underwent surgery and the risk for death or NDI. Surgery was classified as major (the administration of general anesthesia) or minor (without general anesthesia). The study included patients enrolled in the National Institute of Child Health and Human Development Neonatal Research Network Generic Database from 1998 through 2009. A total of 12,111 infants were included in the analyses.

Results: A total of 2,186 infants underwent major surgery, 784 had minor surgery and 9,141 had no surgery. Most infants who underwent surgery did so once, but 1,080 had multiple procedures. Very-low-birth-weight infants who underwent major surgery appeared to have a more than 50 percent increased risk of death or NDI at 18 to 22 months of age. However, in the present analysis, the specific type of anesthesia used was not documented and data on dosing and other drugs administered were not available.

Discussion: "Exposure of VLBW infants to major surgery is associated with increased risk of death or NDI and of NDI among survivors, each by approximately 50%. The contribution of general anesthesia to this effect is suspected but not yet proven."

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(JAMA Pediatr. Published online June 16, 2014. doi:10.1001/jamapediatrics.2014.307. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see article for additional information, including support, other authors, author contributions and affiliations, etc.

Editorial: The Neonatologist's Role in Pediatric Anesthesia Neurotoxicity

In a related editorial, Robert Williams, M.D., of the University of Vermont, Burlington, and colleagues write: "In this context, we welcome the publication by Morriss et al in this issue of the journal. However, as is true with every human neurotoxicity study to date, their work raises as many questions as it answers."

"Consequently, without further specific information regarding the types of anesthesia administered, the conclusions of Morriss et al must remain speculative," the authors continue.

"While we wait for definitive information there is much we can do. At the present time, there is no definitive evidence that exposure to general anesthesia causes neurotoxicity and neither surgery nor anesthesia should be withheld from children if needed," they conclude.

(JAMA Pediatr. Published online June 16, 2014. doi:10.1001/jamapediatrics.2014.469. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see article for additional information, including other authors, author contributions and affiliations, etc.

Media Advisory: To contact author Frank H. Morriss, Jr., M.D., M.P.H., call Jennifer Brown at 319-356-7124 or email jennifer-l-brown@uiowa.edu.

To contact editorial author Robert Williams, M.D., call Jennifer Nachbur at 802-656-7875 or email jennifer.nachbur@uvm.edu. Please visit the JAMA Pediatrics website (http://bit.ly/1adWrco) for an author audio interview after the embargo lifts.



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