Public Release:  No sign of 'obesity paradox' in obese patients with stroke

The JAMA Network Journals

Bottom Line: Researchers found no evidence of an "obesity paradox" (some studies have suggested overweight or obese patients have lower mortality rates than underweight or normal weight patients) in patients with stroke.

Author: Christian Dehlendorff, M.S., Ph.D., of the Danish Cancer Society Research Center, Copenhagen, Denmark, and colleagues.

Background: Obesity often is associated with increased health related complications and death. But some studies have suggested an obesity paradox that may cause some to question striving for a normal weight.

How the Study Was Conducted: The authors sought to determine whether the obesity paradox in stroke was real or an artificial finding because of selection bias in studies. To overcome selection bias, authors only studied deaths caused by the index stroke using a Danish register of stroke and a registry of deaths. The study included 71,617 Danes for whom information was available on factors that included body mass index (BMI), age, stroke type and stroke severity.

Results: Of the 71,617 patients, 7,878 (11 percent) died within the first month and, of these, stroke was reported as the cause of death of 5,512 patients (70 percent). Of the patients for whom BMI information was available, 9.7 percent were underweight, 39 percent were normal weight, 34.5 percent were overweight and 16.8 percent were obese. BMI was inversely related to average age of stroke onset (high BMI associated with younger age of onset).

Discussion: "This study was unable to confirm the existence of an obesity paradox in stroke. ... Obesity was not associated with a lower risk for death after a stroke. ... The risk of obese patients with stroke for death did not differ from that of normal-weight patients with stroke nor was there evidence of a survival advantage associated with being overweight."

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(JAMA Neurol. Published online June 2, 2014. doi:10.1001/.jamaneurol.2014.1017. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Jascha Fonden provided funding for this study. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Media Advisory: To contact corresponding author Tom S. Olsen, M.D., Ph.D., email tso@dadlnet.dk

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