News Release

High stress, hostility, depression linked with increased stroke risk

American Heart Association Rapid Access Journal Report

Peer-Reviewed Publication

American Heart Association

Higher levels of stress, hostility and depressive symptoms are associated with significantly increased risk of stroke or transient ischemic attack (TIA) in middle-age and older adults, according to new research in the American Heart Association journal Stroke.

A TIA is a stroke caused by a temporary blockage of blood flow to the brain.

Researchers investigated how psychological factors might influence risk for chronic disease, using data from the Multi-Ethnic Study of Atherosclerosis (MESA), an ongoing study on cardiovascular disease risk factors in participants living in six U.S. cities.

More than 6,700 adults (ages 45-84; 53 percent women) completed questionnaires assessing chronic stress, depressive symptoms, anger and hostility over two years. Participants were 38.5 percent white, 27.8 percent African-American, 11.8 percent Chinese and 21.9 percent Hispanic. All were free of cardiovascular disease at the start of the study.

In follow-up for an additional 8.5 to 11 years, 147 strokes and 48 TIAs occurred.

Compared to people with the lowest psychological scores, those with highest scores were:

  • 86 percent more likely to have a stroke or TIA for high depressive symptoms.
  • 59 percent more likely to have a stroke or TIA for the highest chronic stress scores.
  • More than twice as likely to have a stroke or TIA for the highest hostility scores.
  • No significant increased risk was linked to anger.

"There's such a focus on traditional risk factors — cholesterol levels, blood pressure, smoking and so forth — and those are all very important, but studies like this one show that psychological characteristics are equally important," said Susan Everson-Rose, Ph.D., M.P.H., study lead author and associate professor of medicine at the University of Minnesota in Minneapolis.

These associations noted in the study were significant even when researchers accounted for age, race, sex, health behaviors and other known risk factors of stroke.

"Given our aging population, it's important to consider these other factors that might play a role in disease risk. Stroke is a disease of the elderly predominantly, and so learning more about things that can influence risk for stroke as people age is important."

Researchers measured chronic stress in five domains: personal health problems, health problems of others close to the participant, job or ability to work, relationships and finances.

They assessed depressive symptoms with a 20-question scale and analyzed anger with a 10-item scale that captured the extent and frequency of experiencing that emotion. Hostility, which is a negative way of viewing the world, was measured by assessing a person's cynical expectations of other people's motives.

"One thing we didn't assess is coping strategies," Everson-Rose said. "If someone is experiencing depressive symptoms or feeling a lot of stress or hostility, we don't know how they manage those, so it's possible that positive coping strategies could ameliorate some of these associations or effects," she said. "We did not inquire about coping. I would say that's one of the tasks for future studies."

Researchers didn't identify potential racial and ethnic differences or sex differences in the observed associations, but were not able to fully examine such differences due to the smaller numbers of strokes in some groups.

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Co-authors are Nicholas Roetker, B.A.; Pamela Lutsey, Ph.D., M.P.H.; Kiarri Kershaw, Ph.D., M.P.H.; W.T. Longstreth Jr., M.D., M.P.H.; Ralph Sacco, M.D., M.S.; Ana Diez Roux, M.D., Ph.D., M.P.H.; Alvaro Alonso, M.D., Ph.D. Author disclosures are on the manuscript.

The National Heart, Lung, and Blood Institute funded the study.

Additional Resources:

  • What is a Stroke?
  • Stress and Heart Health
  • How does depression affect the heart?
  • Follow AHA/ASA news on Twitter @HeartNews.
  • For stroke science, follow the Stroke journal at @StrokeAHA_ASA.

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.heart.org/corporatefunding.


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