Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. Prof. Riyi Shi, who comes from University of Purdue in USA will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of spinal cord injury, and will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following spinal cord injury. The relevant study has been published in Neural Regeneration Research (Vol. 9, No. 7, 2014).
Article: " Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury " by Jonghyuck Park1, 2, Breanne Muratori2, Riyi Shi1, 2 (1 Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA; 2 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA)
Park J, Muratori B, Shi RY. Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury. Neural Regen Res.