Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute cerebral ischemia. Yaning Zhao and her colleagues, Hebei United University, China induced transient whole-brain ischemia by four-vessel occlusion in normal and diabetic rats and intravenously injected diabetic rats with extracellular signal-regulated kinase 1/2 30 minutes before ischemia as a pretreatment. Results showed that during the pathological progression of cerebral ischemia/reperfusion in rats, activation of extracellular signal-regulated kinase 1/2 exhibits protective effect on neuronal injury. Reduced extracellular signal-regulated kinase 1/2 decreases Ku70 activity, increases Bax expression and thereby increases the number of lost hippocampal neurons in diabetic rats after cerebral ischemia/reperfusion. These results were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).
Article: " Regulation of extracellular signal-regulated kinase 1/2 infuences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia," by Yaning Zhao1, Jianmin Li2, Qiqun Tang1, Pan Zhang1, Liwei Jing1, Changxiang Chen1, Shuxing Li1 (1 College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China; 2 Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China)
Zhao YN, Ji JM, Tang QQ, Zhang P, Jing LW, Chen CX, Li SX. Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia. Neural Regen Res. 2014;9(7):749-756.