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PUBLIC RELEASE DATE:
16-Jul-2014

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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research

Who are responsible for protecting against neuron and synapse injury in immature rats?

IMAGE: Through transmission electron microscopy, it is known that fructose-1,6-diphosphate at 1,000 mg/kg administered intraperitoneally can alleviate rough endoplasmic reticulum degranulation (arrow) in hippocampal CA1 region of rats with repeated febrile...

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Fructose-1,6-diphosphate is a metabolic intermediate that promotes cell metabolism. Whether it can alleviate hippocampal neuronal injury caused by febrile convulsion remains unclear. Dr. Jianping Zhou, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, China and his team established a repetitive febrile convulsion model in rats aged 21 days, equivalent to 3𔃃 years in humans, intraperitoneally administered fructose-1,6-diphosphate at 1,000 mg/kg into the rat model. Results showed that high-dose fructose-1,6-diphosphate reduced mitochondrial swelling, rough endoplasmic reticulum degranulation, Golgi dilation and synaptic cleft size, and increased synaptic active zone length, postsynaptic density thickness, and synaptic interface curvature in the hippocampal CA1 area. The present findings suggest that fructose-1,6-diphosphate is a neuroprotectant against hippocampal neuron and synapse damage induced by repeated febrile convulsion in immature rats. These results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

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Article: " Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate," by Jianping Zhou1, Fan Wang2, Jun Zhang3, Hui Gao4, Yufeng Yang5, Rongguo Fu6 (1 Department of Pediatrics, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China; 2 Department of Obstetrics and Gynecology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China; 3 Department of Gastroenterology, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China; 4 Department of Anesthesiology, Yanan University Affiliated Hospital, Yan'an, Shaanxi Province, China; 5 Editorial Board of Chinese Journal of Child Health Care, Xi'an, Shaanxi Province, China; 6 Department of Nephrology, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China)

Zhou JP, Wang F, Zhang J, Gao H, Yang YF, Fu RG. Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate. Neural Regen Res. 2014;9(9):937-942.

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/



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