Public Release:  Vitamin D deficiency raises risk of schizophrenia diagnosis

Studies find people with schizophrenia are more likely to have low levels of vitamin D

The Endocrine Society

Washington, DC -- Vitamin D-deficient individuals are twice as likely to be diagnosed with schizophrenia as people who have sufficient levels of the vitamin, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Vitamin D helps the body absorb calcium and is needed for bone and muscle health. The skin naturally produces this vitamin after exposure to sunlight. People also obtain smaller amounts of the vitamin through foods, such as milk fortified with vitamin D. More than 1 billion people worldwide are estimated to have deficient levels of vitamin D due to limited sunshine exposure.

Schizophrenia is a mental illness with symptoms that can include delusions and hallucinations. Since schizophrenia is more prevalent in high latitudes and cold climates, researchers have theorized vitamin D may be connected to the disorder.

"This is the first comprehensive meta-analysis to study the relationship between the two conditions," said one of the study's authors, Ahmad Esmaillzadeh, PhD, of the Isfahan University of Medical Sciences in Isfahan, Iran. "When we examined the findings of several observational studies on vitamin D and schizophrenia, we found people with schizophrenia have lower vitamin D levels than healthy people. Vitamin D deficiency is quite common among people with schizophrenia."

The researchers reviewed the findings of 19 observational studies that assessed the link between vitamin D and schizophrenia. Combined, the studies looked at vitamin D levels and the mental health of 2,804 adult participants. The studies used blood tests to determine each participant's vitamin D levels.

The meta-analysis found that people with schizophrenia had significantly lower levels of vitamin D in the blood compared to the control groups. The average difference in vitamin D levels between schizophrenic patients and control participants was -5.91 ng/ml. People with vitamin D deficiency were 2.16 times more likely to have schizophrenia than those with sufficient vitamin D in their bloodstreams. In addition, 65 percent of the participants who had schizophrenia also were vitamin D deficient.

"There is a growing trend in the nutrition science field to consider vitamin D and its relationship to conditions such as diabetes, cancer, heart disease and depression," Esmaillzadeh said. "Our findings support the theory that vitamin D may have a significant impact on psychiatric health. More research is needed to determine how the growing problem of vitamin D deficiency may be affecting our overall health."

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Other authors of the study include Ghazaleh Valipour and Parvane Saneei of the Isfahan University of Medical Sciences.

The study, "Serum Vitamin D Levels in Relation to Schizophrenia: A Systematic Review and Meta-analysis of Observational Studies," was published online, ahead of print.

Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 17,000 scientists, physicians, educators, nurses and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at https://twitter.com/#!/EndoMedia.

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