[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:
28-Jul-2014

[ | E-mail ] Share Share

Contact: Anita Srikameswaranat
srikamav@upmc.edu
412-578-9193
The JAMA Network Journals
www.twitter.com/JAMA_current

Research letter examines pacemaker use in patients with cognitive impairment

Dr. Nicole R. Fowler and her fellow reserachers have found that patients with dementia were more likely to receive a pacemaker then patients without cognitive impairment.

Older adults with mild cognitive impairment (MCI) and dementia can have co-existing cardiac illnesses and that makes them eligible for therapy with devices to correct rhythm abnormalities. But the risks and benefits need to be weighed carefully with patients, families and clinicians.

The authors examined data from the National Alzheimer Coordinating Center Uniform Data Set gathered from 33 Alzheimer Disease Centers from September 2005 through December 2011. There were 16,245 participants with a baseline visit and at least one follow-up.

At baseline, 7,446 participants (45.8 percent) had no cognitive impairment, 3,460 (21.3 percent) had MCI and 5,339 (32.9 percent) had dementia. Participants who had dementia at the visit before being assessed for a pacemaker were 1.6 times more likely to receive a pacemaker compared with participants without cognitive impairment and participants with MCI were 1.2 times more likely. Over the seven-year study period, rates of pacemakers were 4 per 1,000 person-years for participants without cognitive impairment, 4.7 per 1,000 person-years for participants with MCI and 6.5 per 1,000 person-years for participants with dementia.

Patients with dementia were more likely to receive a pacemaker than patients without cognitive impairment, even after adjusting for clinical risk factors. This runs counter to the normative expectation that patients with a serious life-limiting and cognitively disabling illness might be treated less aggressively. While it is possible that unmeasured confounding by indication explains this observation, future research should explore the patient, caregiver and clinician influences on decision making regarding cardiac devices in this population.

###

JAMA Intern Med. Published online July 21, 2014. doi:10.1001/jamainternmed.2014.3450.

This study was supported by grants from the Agency for Healthcare Research and Quality and the National Institutes of Health, National Institute on Aging. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.



[ Back to EurekAlert! ] [ | E-mail Share Share ]

 


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.