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PUBLIC RELEASE DATE:
30-Jul-2014

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Contact: Jagat Narula
jagat.narula@mountsinai.org
212-241-2836
World Heart Federation

Our genes have made us susceptible to atherosclerosis, while our environment determines its speed and severity

In the editorial introducing this month's edition of Global Heart (the journal of the World Heart Federation), the authors ask: "Why do humans develop atherosclerosis?* Is the human genome hardwired to develop atherosclerosis? Can atherosclerosis be entirely prevented? Is atherosclerosis fundamental to the aging process? Have the risk factors that have contributed to the development of atherosclerosis been the same all along human evolution?" The editorial is by Dr Gregory Thomas, Medical Director, MemorialCare Heart & Vascular Institute, Long Beach Memorial, Long Beach, CA; USA; Dr Samuel Wann, Columbia St. Mary's Healthcare, Milwaukee, WI, USA; and Professor Jagat Narula, Editor-in-Chief of Global Heart and Associate Dean for Global Health at Icahn School of Medicine at Mount Sinai, New York, USA.

Reviewing the related studies in the issue, the editors comment: "Using x-ray computed tomography (CT), the investigators contributing to this issue of Global Heart have yet to find a culture that did not have pre-clinical atherosclerosis. Unfortunately, like Ponce de León, they did not find an atherosclerosis 'fountain of youth'."

The international, interdisciplinary Horus mummy research team explored the prevalence and potential causes of atherosclerosis, by CT scanning ancient people across the globe. Professor Narula and Dr Wann comment on the findings, "The melding of archaeology, anthropology, paleopathology, and medical science created the opportunity to develop new insights into atherosclerosis. Cross fertilisation of seemly unrelated disciplines and re-examination of common and uncommon diseases in the light of new data and capabilities from such disciplines harbours great potential for new discoveries not only in cardiology but across the field of medicine."

The editors conclude: "The work of the Horus and other research teams suggests that genetically humans are inherently susceptible to atherosclerosis. However, the environment in which humans live, the choices they make, to be active, to avoid smoking, and staying lean, all contribute to determining when in life atherosclerosis will strike." As Horus team member, Dr Michael I Miyamoto of Mission Heritage Medical Group suggests, "As humans we want to die with atherosclerosis, not because of atherosclerosis."

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*Note to editors: atherosclerosis=narrowing of the arteries due to build up of fatty deposits



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