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PUBLIC RELEASE DATE:
20-Aug-2014

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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research

Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

IMAGE: 150 mg/kg Shuganjieyu capsule significantly increased brain-derived neurotrophic factor expression in the medial prefrontal cortex of rats with depressive-like behaviors (immunohistochemical staining).

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Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. Prof. Jingping Zhao and team from the Second Xiangya Hospital, Central South University in China conducted a study to examine the effect of Shuganjieyu capsule on behavioral changes in a rat model of depression. They focused on the underlying mechanisms of Shuganjieyu capsule by examining brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels in the medial prefrontal cortex and hippocampal CA3 area. The results presented in this study demonstrate that Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing brain-derived neurotrophic factor and phosphorylated cyclic adenosine monophosphate response element binding protein expression levels in the medial prefrontal cortex and hippocampalCA3 area of depressive-like rats, which may be one of the anti-depressant mechanisms of Shuganjieyu capsule. This study has been published in the Neural Regeneration Research.

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Article: " Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression," by Jinhua Fu1, 2, Yingjin Zhang3, Renrong Wu1, Yingjun Zheng4, Xianghui Zhang1, Mei Yang2, Jingping Zhao1, Yong Liu1 (1 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, China; 2 Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China; 3 Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 4 Guangzhou Brain Hospital, Affliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, China)

Fu JH, Zhang YJ, Wu RR, Zheng YJ, Zhang XH, Yang M, Zhao JP, Liu Y. Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression. Neural Regen Res. 2014;9(5):489-497

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/



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