Researchers at Moffitt Cancer Center, including Center Director Thomas A. Sellers, Ph.D., M.P.H., Jong Park, Ph.D. and Hui-Yi Lin, Ph.D., have discovered 23 new regions of the genome that influence the risk for developing prostate cancer, according to a study published Sept. 14 in Nature Genetics.
Prostate cancer is the most common non-skin cancer in American men. About 1 in 6 men will be diagnosed with the disease in his lifetime. Family history is the strongest risk factor. A man with one close relative, a brother or father with prostate cancer is twice as likely to develop the disease as a man with no family history of prostate cancer.
This study brings the number of genetic variants linked to prostate cancer to 100. Testing for those variants can identify men with a risk of the disease that is almost six times higher than average.
"This study gives us a more complete list of genetic factors that increase a man's prostate cancer risk. The goal is to now take this information and use it to develop a reliable test that can be used in addition to current screening methods," said Park.
The collaborative effort, which included scientists from The Institute of Cancer Research, University of Cambridge and the National Institutes of Health, conducted a large-scale analysis of nearly 90,000 men to identify novel inherited factors that contribute to prostate cancer. For the first time, the researchers looked at men from all over the world, including those of European, African, Japanese and Latino ancestry.
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Moffitt is the top-ranked cancer hospital in the Southeast and has been listed in U.S. News & World Report as one of the "Best Hospitals" for cancer since 1999. With more than 4,500 employees, Moffitt has an economic impact on Florida of nearly $1.6 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, Twitter and YouTube.
Journal
Nature Genetics