Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. According to a recent study reported in the Neural Regeneration Research, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
"APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease," by Qin Zhou , Dantao Peng , Xinrui Yuan , Zeping Lv , Shenghang Pang , Wenyu Jiang , Chuyu Yang , Xiaohong Shi , Guofang Pang , Yige Yang1, Haiqun Xie2, Wandong Zhang3, Caiyou Hu2, Ze Yang1 (1 Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China；2 Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China；3 Human Health Therapeutics, National Research Council of Canada, Ottawa, Canada)
Zhou Q, Peng DT, Yuan XR, Lv ZP, Pang SH, Jiang WY, Yang CY, Shi XH, Pang GF, Yang YG, Xie HQ, Zhang WD, Hu CY, Yang Z. APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease. Neural Regen Res. 2014;9(6):653-660.