Public Release:  Brain scans link frontal abnormalities to suicidal behaviors in adolescents, young adults

American College of Neuropsychopharmacology

Phoenix, AZ (December 9th, 2014) - Abnormalities in the prefrontal cortex and related brain areas are observed in adolescents who have attempted suicide, according to a report today at the American College of Neuropsychopharmacology annual meeting in Phoenix Arizona. The study suggests that deficits in frontal systems may be associated with risk for suicide attempts in youths with mood disorders.

Most suicide attempts occur in the context of mood disorders, including bipolar disorder and major depressive disorder. Bipolar disorder has a prevalence of 3-4% in the U.S. population, and 25-50% of those affected attempt suicide; 15-20 % of individuals with the disorder die as a result. Early intervention is needed as suicidal behavior often first presents in adolescence. The development of new interventions, however, requires a better characterization of how features of brain structure and function are linked to the development of suicidal behaviors.

Using magnetic resonance imaging (MRI), Hilary Blumberg and colleagues at the Yale School of Medicine examined brain structure and function in adolescents and young adults, 14 - 25 years of age. Sixty-eight participants with bipolar disorder, of whom 26 attempted suicide, were compared with 45 healthy volunteers matched for age and gender. The investigators found that, compared with bipolar patients who did not attempt suicide and healthy control subjects, the participants who attempted suicide showed less integrity of white matter in key frontal brain systems, including the uncinate fasciculus, a fiber tract that connects the frontal lobe with key brain areas that control emotion, motivation, and memory. What was remarkable was that the deficits in the structural connections were linked to weaker connections between the prefrontal cortex and amygdala, suggesting that the white matter abnormalities disrupt the ability of these system components to work together. Further, there were links between the circuitry deficits and suicidal ideation, the number of suicide attempts and the relative lethality of those prior suicide attempts.

This work presents an important first step in understanding the neurobiology of how suicidal thoughts and behaviors are generated and may facilitate earlier identification of individuals at risk and development of targeted interventions to stop suicide.

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This work was supported by grants from the National Institute on Mental Health, the American Foundation for Suicide Prevention, and the International Bipolar Foundation.

Media contact: william.hathaway@yale.edu

ACNP, founded in 1961, is a professional organization of more than 700 leading scientists, including four Nobel Laureates. The mission of ACNP is to further research and education in neuropsychopharmacology and related fields in the following ways: promoting the interaction of a broad range of scientific disciplines of brain and behavior in order to advance the understanding of prevention and treatment of disease of the nervous system including psychiatric, neurological, behavioral and addictive disorders; encouraging scientists to enter research careers in fields related to these disorders and their treatment; and ensuring the dissemination of relevant scientific advances.

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