Public Release:  A brain system that appears to compensate for autism, OCD, and dyslexia

Georgetown University Medical Center

WASHINGTON -- Individuals with five neurodevelopmental disorders -- autism spectrum disorder, obsessive-compulsive disorder, Tourette syndrome, dyslexia, and Specific Language Impairment -- appear to compensate for dysfunction by relying on a single powerful and nimble system in the brain known as declarative memory.

This hypothesis being proposed by a Georgetown University Medical Center neuroscientist is based on decades of research. It is published online and will be in the April issue of Neuroscience and Biobehavioral Reviews.

The proposed compensation allows individuals with autism to learn scripts for navigating social situations; helps people with obsessive-compulsive disorder or Tourette syndrome to control tics and compulsions; and provides strategies to overcome reading and language difficulties in those diagnosed with dyslexia, autism, or Specific Language Impairment, a developmental disorder of language.

"There are multiple learning and memory systems in the brain, but declarative memory is the superstar," says Michael Ullman, PhD, professor of neuroscience at Georgetown and director of the Brain and Language Laboratory. He explains that declarative memory can learn explicitly (consciously) as well as implicitly (non-consciously).

"It is extremely flexible, in that it can learn just about anything. Therefore it can learn all kinds of compensatory strategies, and can even take over for impaired systems," says Ullman.

"Nevertheless, in most circumstances, declarative memory won't do as good a job as these systems normally do, which is an important reason why individuals with the disorders generally still have noticeable problems despite the compensation," he adds.

Knowing that individuals with these disorders can rely on declarative memory leads to insights on how to improve diagnosis and treatment of these conditions. It could improve treatment in two ways, Ullman says. First, designing treatments that rely on declarative memory, or that improve learning in this system, could enhance compensation. Conversely, treatments that are designed to avoid compensation by declarative memory may strengthen the dysfunctional systems.

Ullman says compensation by declarative memory may also help explain an observation that has long puzzled scientists -- the fact that boys are diagnosed with these disorders more frequently than girls. "Studies suggest that girls and women are better than boys and men, on average, in their use of declarative memory. Therefore females are likely to compensate more successfully than males, even to the point of compensating themselves out of diagnosis more often than males," Ullman says.

Declarative memory may also compensate for dysfunctions in other disorders, he adds, including attention deficit hyperactivity disorder (ADHD) and even adult-onset disorders such as aphasia or Parkinson's disease.

The hypothesis may thus have powerful clinical and other implications for a wide variety of disorders. Ullman says.

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Support for this research was provided by the National Institutes of Health (RO1 HD049347), the Simons Foundation, and the Mabel H. Flory Trust.

Mariel Pullman, a former research assistant in Ullman's lab and current medical student, is co-author.

About Georgetown University Medical Center

Georgetown University Medical Center (GUMC) is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through MedStar Health). GUMC's mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis -- or "care of the whole person." The Medical Center includes the School of Medicine and the School of Nursing & Health Studies, both nationally ranked; Georgetown Lombardi Comprehensive Cancer Center, designated as a comprehensive cancer center by the National Cancer Institute; and the Biomedical Graduate Research Organization, which accounts for the majority of externally funded research at GUMC including a Clinical and Translational Science Award from the National Institutes of Health.

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