Public Release:  Study finds autism, ADHD run high in children of chemically intolerant mothers

Mothers with chemical intolerances are 2-3 times more likely than other women to have a child with autism or ADHD, according to a new study by the University of Texas Health Science Center at San Antonio

University of Texas Health Science Center at San Antonio

A new study from The University of Texas Health Science Center at San Antonio found that mothers with chemical intolerances are two to three times more likely than other women to have a child with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD).

The medical study was published in the July-August 2015 issue of the Journal of the American Board of Family Medicine.

People who are chemically intolerant often have serious reactions to common chemicals and some become too sick to carry out routine functions. Chemical intolerance affects about 10 percent to 30 percent of the U.S. population. Developmental disorders such as autism and attention-deficit disorder affect one in six children in the United States.

The study included 282 mothers of children who had ASD and 258 mothers of children diagnosed with ADHD. The control group consisted of 154 mothers whose children had no developmental disorders.

The study was based on maternal responses to the Quick Environmental Exposure and Sensitivity Inventory, or QEESI, a 50-question survey used by physicians worldwide to diagnose chemical intolerance.

"We are most concerned about how vulnerable the children with ADHD and autism were to environmental exposures," said the primary author, Lynne P. Heilbrun, M.P.H., autism research coordinator for the Department of Family and Community Medicine at the UT Health Science Center San Antonio. "Mothers reported that their children were significantly more sensitive to everyday exposures such as engine exhaust, gasoline, smoke, fragrances and cleaners than their neurotypical peers." The children reportedly also were more sensitive to adverse effects from infections, medications, chemicals, foods and allergens, the authors said.

The authors said chemically intolerant mothers were three times more likely to report having a child with ASD and 2.3 times more likely to have a child with ADHD. The study did not assess fathers.

Mothers in the study who had a child with ASD or ADHD reported that their children had more illnesses or symptoms associated with chemical intolerance than control mothers.

  • The children with ADHD were 1.7 times more likely than control children (ASD were 4.9 times more likely) to have had multiple infections requiring prolonged use of antibiotics.
  • Children with ADHD were twice as likely as control children (ASD were 1.6 times more likely) to have allergies.
  • Children with ADHD were twice as likely (ASD were 3.5 times more likely) to have had nausea, headaches, dizziness or trouble breathing when exposed to smoke, nail polish remover, engine exhaust, gasoline, air fresheners or cleaning agents than control children.
  • Children with ADHD were twice as likely as controls (ASD were 4.8 times more likely) to have strong food preferences or cravings for cheese, chips, bread, pasta, rice, sugar, salt and chocolate.

"The American College of Obstetrics and Gynecology issued a consensus statement in 2013 saying that there is sufficient evidence linking toxic exposures to adverse birth and developmental outcomes, calling for physicians to inform women to avoid specific environmental exposures even before conception. Studies that linked tobacco and alcohol to neurological disorders were available for decades before recommendations to avoid these became a major public health initiative. Physicians have the opportunity right now to become proactive in helping mothers protect their children from neurological disorders plaguing U.S. families," Heilbrun said.

The authors recommend that all mothers and pregnant women adopt preventive measures to avoid potentially harmful chemicals. Preventive measures include avoiding exposure to pesticides, solvents, combustion products, and chemicals used during construction and remodeling.

The authors urged doctors to use the QEESI to assess patients for potential chemical intolerance. Senior author Claudia S. Miller, M.D., professor emeritus at the Health Science Center and a visiting senior scientist for the Harvard School of Public Health, said, "It's important for everyone to know that doctors can use a readily available tool to identify more susceptible mothers and to suggest environmental interventions to help protect themselves and their developing children."

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The study's co-authors are Carlos R. Jaén, M.D., professor and chair of the Department of Family and Community Medicine, and Raymond F. Palmer, Ph.D., associate professor in the Department of Family and Community Medicine, both at the UT Health Science Center San Antonio; Jimmy L. Perkins, Ph.D., San Antonio; and Melissa D. Svoboda, M.D., Children's Hospital of San Antonio/Baylor College of Medicine (Department of Pediatrics).

The University of Texas Health Science Center at San Antonio, one of the country's leading health sciences universities, ranks in the top 13 percent of academic institutions receiving National Institutes of Health (NIH) funding. The university's schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 31,000 graduates. The $787.7 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways "We make lives better®," visit http://www.uthscsa.edu.

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