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Researchers gauge heritability of childhood-onset autoimmune diseases

CHOP-led genomics analysis may advance disease risk assessments, precision medicine efforts

Children's Hospital of Philadelphia

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IMAGE: Hakon Hakanarson, M.D., Ph.D., is the director of the Center for Applied Genomics at the Children's Hospital of Philadelphia. view more

Credit: The Children's Hospital of Philadelphia

Scientists have calculated more precise measurements of heritability--the influence of underlying genes--in nine autoimmune diseases that begin in childhood. The research may strengthen researchers' abilities to better predict a child's risk for associated autoimmune diseases.

Autoimmune diseases, such as type 1 diabetes, Crohn's disease and juvenile idiopathic arthritis, collectively affect one in 12 persons in the Western Hemisphere. They represent a significant cause of chronic disability.

"The results from this study enable us to better understand the genetic component of these diseases and how they are genetically related to each other, thereby explaining why different autoimmune disorders often run in the same family," said study leader, Hakon Hakonarson, M.D., Ph.D., professor of Pediatrics and director of the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP).

The study appears online today in Nature Communications. Co-authors contributed gene data from more than 20 hospitals and research centers in the U.S. and overseas.

The research encompassed nine pediatric-onset autoimmune diseases (pAIDs): type 1 diabetes, celiac disease, juvenile idiopathic arthritis, common variable immunodeficiency, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, psoriasis, and ankylosing spondylitis. The study team compared genome-wide association study data from those diseases to data from pediatric-onset epilepsy, a non-autoimmune disease. In all, the study team analyzed data from over 5,000 unrelated pAID patients drawn from the CHOP pediatric network and from 36,000 healthy controls.

Because many autoimmune diseases run in families and because individual patients often suffer from more than one condition, clinicians have long suspected the existence of an overlapping genetic landscape. The current study team used recently developed research tools for their quantitative analysis, calculating the percentages that specific gene variants contribute to each disease. The researchers also calculated joint heritability attributable to common gene variants shared by pairs of diseases.

The two diseases with the highest heritability were type 1 diabetes (T1D) and juvenile idiopathic arthritis (JIA). Two forms of inflammatory bowel disease, ulcerative colitis and Crohn's disease, had lower rates of heritability--in line with other research showing the influence of environmental factors such as gastrointestinal microorganisms in those diseases.

In general, the pAIDs had stronger heritability than that previously found in adult-onset autoimmune diseases. This makes biological sense, said Hakonarson, because children have had a shorter time than adults for environmental exposures to have an effect.

Among disease pairs, ulcerative colitis and Crohn's disease had the strongest correlations, as did JIA and common variable immunodeficiency.

This study complements research led by Hakonarson and his graduate student Yun Rose Li (first author of the current study) published earlier this year in Nature Medicine that reported overlapping gene variants among multiple pAIDs. Those findings suggested opportunities for drug targeting and for advancing the potential of precision medicine to individualize therapies according to a patient's genetic profile.

"We envision that we may be able to develop new therapies that may help significant subsets of patients across multiple autoimmune diseases who share the same genetic variants that result in perturbations of normal biological functions and autoimmunity," said Hakonarson, who added, "This is the foundation for precision medicine approaches."

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Funds from the National Institutes of Health (grants DK085708, AR058606, HG006830, and AR066486), the Paul and Daisy Soros Fellowship for New Americans, the Crohn's & Colitis Foundation of America, the Juvenile Diabetes Research Foundation, the Lupus Research Institute, and Institutional Development Funds from The Children's Hospital of Philadelphia supported this research. In addition to his CHOP position, Hakonarson is on the faculty of the Perelman School of Medicine at the University of Pennsylvania.

"Genetic Sharing and Heritability of Pediatric Age-of-Onset Autoimmune Diseases," Nature Communications, published online Oct. 9, 2015. http://doi.org/10.1038/NCOMMS9442

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. In addition, its unique family-centered care and public service programs have brought the 535-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

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