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Planned repeat C-section not linked to worse child health than vaginal birth after C-s

PLOS

Study finds planned repeat cesarean section not linked to worse child health than vaginal birth after cesarean section.

Long-term health outcomes in children of mothers with planned cesarean sections (CS) are not substantially worse than those children of mothers with vaginal births after cesarean section (VBAC), according to a study published by Mairead Black and colleagues from the University of Aberdeen, United Kingdom, in this week's PLOS Medicine.

The researchers studied all second births (N=40,145) between 1993 and 2007 of children to mothers in Scotland who had previously had a first child born by CS. Using available health records, they categorized these births into scheduled repeat CS (assumed to be planned) (44.6%), unscheduled repeat CS (22.1%), and VBAC (33.3%) and looked for correlations between type of birth and several health outcomes in children, including obesity at age five years, hospitalization with asthma, prescription of a salbutamol inhaler (an asthma medication) at age five, hospitalization with irritable bowel disease, type 1 diabetes, learning disability, cerebral palsy, cancer, and death. The only consistent difference the researchers found between repeat CS (both scheduled or unscheduled) and VBAC was a slightly elevated risk for hospitalization with asthma in children born by CS. They felt that this was not clinically significant, especially as there was no difference in the rate of salbutamol inhaler prescription. They also observed that learning disability and death were more common following unscheduled CS but not scheduled CS compared with VBAC.

While findings here suggest that there are no substantially worse outcomes associated with planned repeat CS births, it is not known whether the births analyzed in this study were initially planned to be vaginal or CS. The researchers assumed an intended CS was one that was scheduled ahead of time and performed on the scheduled date, and all other CS were categorized as unplanned and likely represent a mix of emergency CS ahead of a planned CS, and emergency CS after complications during a planned vaginal birth.

The authors say: "The lack of data on intended (rather than actual) mode of birth limits the direct application of these study findings to clinical practice, but women may be somewhat reassured by the apparent lack of risk to long-term offspring health following planned repeat CS specifically. This study may therefore support the process of planning birth after CS in a way that reflects women's values and preferences."

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Research Article

Funding: MB receives funding from Wellcome Trust as part of a research training fellowship. Wellcome Trust did not play any role in the design, conduct or reporting of this study.

Competing Interests: JEN has declared the following competing interests: "I have grants from government bodies and charities for research into preterm birth stillbirth and the consequences of obesity in pregnancy. I also sit (unpaid) on a DMC for Glaxo Smith Kline." The remaining authors have declared that no competing interests exist.

Citation: Black M, Bhattacharya S, Philip S, Norman JE, McLernon DJ (2016) Planned Repeat Cesarean Section at Term and Adverse Childhood Health Outcomes: A Record-Linkage Study. PLoS Med 13 (3): e1001973. doi:10.1371/journal.pmed.1001973

Author Affiliations:

Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom;

Diabetes Research Unit, NHS Grampian, Aberdeen, United Kingdom;

Tommy's Centre for Maternal and Fetal Health, University of Edinburgh, Edinburgh, United Kingdom;

Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001973

Contact:

Mairead Black
University of Aberdeen
Division of Applied Health Sciences
Dugald Baird Centre
Aberdeen Maternity Hospital
Cornhill Road
Aberdeen, AB25 2ZDL
UNITED KINGDOM
01224 438420
mairead.black@abdn.ac.uk

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