image: This graphic illustrates mutations and bioinformatic analysis. view more
Credit: Jakob Skou, Philippe Lamy
Bladder cancer is a frequent disease affecting approximately 1,900 persons in Denmark annually. A high number of these patients only have superficial tumours in the bladder when the disease is diagnosed. For many years, this patient group will be examined frequently and during this time many get new tumours; some cases develop aggressively making it necessary to remove the bladder or receive chemotherapy.
A research team from Aarhus University Hospital and Aarhus University headed by professor Torben Ørntoft and professor Lars Dyrskjøt has been in charge of a larger European research project mapping the molecular mechanisms of early stages of bladder cancer in 460 patients in Denmark, Sweden, The Netherlands, Germany, Spain and Serbia. The researchers found that tumours can be divided into three primary classes with very different molecular and disease-developing characteristics. These findings may be important in risk assessment and subsequent choice of treatment.
The researchers found that bladder tumours from the molecular group with high risk of developing aggressive disease contain mutations in genes and molecular pathways often associated with later stages of the disease. Moreover, the researchers observed changes in genes involved in genome structure regulation in 86% of the tumours. This new knowledge can facilitate use of new drugs targeted at these specific changes.
"This study provides new and valuable insight into the biology of the tumours in the earliest stages of the disease. Clinical and pathological examinations of the individual tumours do not always reflect the risk of later disease aggressiveness. This study provides a tool for risk assessment of the patients and thus for providing optimal treatment", says professor Lars Dyrskjøt from Department of Molecular Medicine, Aarhus University Hospital.
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The research results will be published in the prestigious scientific journal Cancer Cell:
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma. Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhø BP3, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MBH, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic T, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel K, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, and Dyrskjøt L. Cancer Cell 30, 1-16, July 11, 2016
Journal
Cancer Cell