Stimulating a precise location of the brain's memory center with electromagnetic pulses improves the memory of older adults with age-related memory loss to the level of young adults, reports a new study. The study used Transcranial Magnetic Stimulation to target the hippocampus -- the brain region that atrophies as people grow older, which is responsible for memory decline.
A team led by Senthil Muthuswamy, PhD, at the Cancer Center at Beth Israel Deaconess Medical Center, has discovered an unexpected relationship between levels of the amino acid leucine (found in beef, chicken, pork and fish and other foods) and the development of tamoxifen resistance in ER+ breast cancer. These findings reveal a potential new strategy for overcoming resistance to endocrine drugs in ER+ breast cancer patients.
Chronic bacterial infections in the lungs of cystic fibrosis patients are worsened by a previously unappreciated biological agent: a group of viruses that infect the bacteria. The viruses form a biofilm that sequesters antibiotics away from bacteria, potentially contributing to the development of antibiotic resistance in CF patients' lungs, a new study from the Stanford University School of Medicine has found.
A study of samples from 92 patients with cystic fibrosis (CF) has revealed that certain bacteriophages -- viruses that infect bacteria -- worsen the severity of bacterial infections associated with the disorder.
Reducing the sugar content of certain foods by 2020, in line with UK government policy targets, could cut child obesity and related illness, and save the NHS in England £286 million over 10 years, suggests a study published by The BMJ today.
Circulation and cellular activity were restored in a pig's brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death, Yale scientists report April 18 in the journal Nature.
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions. With funding through the NIH BRAIN Initiative, researchers developed a way to deliver an artificial blood supply to the isolated postmortem brain of a pig, preventing the degradation that would otherwise destroy many cellular and molecular functions and render it unsuitable for study.
In a small, pilot study, a non-invasive device that uses magnetic fields to stimulate nerve cells in the brain was associated with temporary improvements in age-related memory loss in older people, according to a study published in the April 17, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A small clinical trial has shown that gene therapy can safely correct the immune systems of infants newly diagnosed with a rare, life-threatening inherited disorder in which infection-fighting immune cells don't develop or function normally. Eight infants with the disorder, called X-linked severe combined immunodeficiency (X-SCID), received experimental gene therapy co-developed by NIH scientists. They experienced substantial improvements in immune system function and normal growth up to two years after treatment.
Regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens, according to a report published online in NEJM. Results of the Phase 2, open-label study indicate the antibody, known as UB-421, was safe and did not induce the production of antibody-resistant HIV.