Massachusetts General Hospital investigators have discovered the mechanism by which cells sense dysfunction of the proteasome -- a cellular component that degrades unneeded or defective proteins -- and respond in a previously undescribed manner, by editing the amino acid sequence of a key sensing protein.
Vaginal dryness and painful intercourse are some of the more common adverse events of post-breast cancer treatment therapies and often lead to sexual dissatisfaction and an overall lower quality of life (QOL). However, a new study finds that partnered women may fare better than those without a partner. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
Researchers from King's College London, Harvard and INSERM-Paris have discovered a new way to measure brain function in milliseconds using magnetic resonance elastography (MRE). This could help with diagnosing and understanding neurological diseases like Alzheimer's, dementia, multiple sclerosis, or epilepsy.
Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate -- an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
Stimulating a precise location of the brain's memory center with electromagnetic pulses improves the memory of older adults with age-related memory loss to the level of young adults, reports a new study. The study used Transcranial Magnetic Stimulation to target the hippocampus -- the brain region that atrophies as people grow older, which is responsible for memory decline.
In a small, pilot study, a non-invasive device that uses magnetic fields to stimulate nerve cells in the brain was associated with temporary improvements in age-related memory loss in older people, according to a study published in the April 17, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
UBC researchers have determined the majority of men struggle when it comes to understanding the diagnosis and treatment of prostate cancer. Professors Joan Bottorff and John Oliffe are scientists with UBC's Men's Health Research Program. Together, while studying men's knowledge or literacy of prostate cancer, they realized many are in the dark when it comes to what they know about the disease. And, more importantly, what direction to take after diagnosis.
Inflammation gone awry in the brain due to stroke, head injury or infection causes damage; in a lab model of stroke, a particular gene tamped down swelling.
Close to one in two cases of dementia could be preventable in low- to middle-income countries, finds a new UCL study. The findings, published in The Lancet Global Health, found how improving childhood education and other health outcomes throughout life could reduce the risk of dementia.
Low scam awareness in older people is associated with risk for developing Alzheimer dementia or mild cognitive impairment in the future. These findings suggest that changes in social judgment occur before changes in thinking or memory are recognizable. Findings from a prospective cohort study are published in Annals of Internal Medicine.