Research from Rohit N. Kulkarni's lab at Joslin Diabetes Center has uncovered a biomarker in humans tied to the development of Non-Alcoholic Fatty Liver Disease that might help doctors detect early stages of the disease. The researchers also determined that this biomarker, a protein known as 'neuronal regeneration related protein' (or NREP), plays a significant role in the regulation of a pathway that is currently being reviewed in clinical trials as a treatment option for the disease.
In people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies against heart muscle proteins was associated with cardiac magnetic resonance (CMR) imaging evidence of increased volume of the left ventricle (the heart's main pumping chamber), increased muscle mass, and reduced pumping function (ejection fraction), features that are associated with higher risk of failure in the general population
Researchers in the lab of Joslin's Yu-Hua Tseng, PhD, a Senior Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center, have discovered an unexpected biological pathway by which brown fat cells can translate energy into heat.
A new study in the American Journal of Preventive Medicine, published by Elsevier, reports valuable new grip strength metrics that provide healthcare practitioners with an easy-to-perform, time-efficient screening tool for type 2 diabetes (T2DM).
What combination of healthy lifestyle factors were associated with the most years lived without chronic diseases was the focus of this analysis that included data from more than 100,000 adults who were participants in 12 European studies.
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 -- a member of the BCL2 protein family known as the gatekeepers of apoptosis -- and the cell-cycle checkpoint protein P18. Through this link, MCL1, which functions in the decision between either cell survival or programmed death, can also directly initiate cell proliferation.
A larger thigh circumference may be associated with lower blood pressure and a reduced risk of heart disease in people with obesity, according to a study published in Endocrine Connections. In overweight and obese Chinese men and women, larger thigh circumferences were associated with lower blood pressure. These findings suggest that carrying more weight on the thighs may be a marker of better heart health in Chinese obese and overweight people, who are at a greater risk of heart disease.
Doctors need to pay particular attention to patients with endocrine disorders and diabetes mellitus in relation to COVID-19 infections, say leading endocrinologists.
A research team led by scientists from Tokyo University of Agriculture and Technology (TUAT), Japan, has successfully established 3D cultured tissue that mimics liver fibrosis, a key characteristic of non-alcoholic steatohepatitis (NASH). For making the 3D culture, cells were collected from liver tissues of NASH model mice. Their findings open up a new avenue for developing drugs for NASH patients, identifying new markers for early diagnosis, and better understanding the disease progression.
In a new study published in Nature Communications, Michigan researchers reveal a pathway by which the hormone leptin contributes to weight loss.