A research team at Children's Hospital of Philadelphia has developed an innovative computational tool offering researchers an efficient method for detecting the different ways RNA is pieced together (spliced) when copied from DNA. Because variations in how RNA is spliced play crucial roles in many diseases, this new analytical tool will provide greater capabilities for discovering disease biomarkers and therapeutic targets, even from RNA-sequencing data sets with modest coverage.
Anticipatory waivers of consent for pediatric biobanking, a case study of unethical US experiments in Guatemala, and more in the current issue of Ethics & Human Research.
The Chinese Famine of 1959-61 has been widely interpreted as an important contributor to later epidemics of Type 2 Diabetes Mellitis (T2DM, but in re-examining 17 related Chinese studies researchers at Columbia University Mailman School of Public Health and Leiden University Medical Center, found little evidence for this association.
As FDA approval of the first postpartum depression drug hits the news, study looks at how infant fussiness and a baby's level of prematurity may influence the severity of maternal depressive symptoms.
When treating patients, doctors sometimes overlook how their decisions impact a world they never see: a patient's home life. In the case of some serious infections in children, oral antimicrobial drugs are just as good at treating these ailments at home as the standard, intravenous medications. But according to new research led by investigators at University of Utah Health, by-mouth medications excel in the important measure of preserving parents' quality of life.
This observational study looked at the extent of racial segregation and inequality of care for very low-birth-weight and very preterm infants at neonatal intensive care units (NICUs) across the United States.
This randomized clinical trial of 71 children with autism spectrum disorder (ASD) tested a wearable behavioral intervention deployed on Google Glass and worn by children at home to reinforce facial engagement and emotion recognition to improve social behavior.
Traditional print books may have an edge over e-books when it comes to quality time shared between parents and their children, a new study suggests.
Dr. Andrew Dauber, a pediatric endocrinologist, guides two poster presentations and an oral abstract at ENDO 2019. This research forms a case study about using genomics and electronic health records to screen and diagnose severe growth disorders. In some cases, this has led to further testing -- WES, microarray samples -- and to the discovery of novel variants for height disorders.
Endocrine-disrupting chemicals present in household dust promote the development of fat cells in a cell model and could contribute to increased growth in children relative to their age, according to research to be presented Monday, March 25, at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.