Discovering antiviral and anticancer drugs will soon be faster and cheaper thanks to new research from Simon Fraser University chemist Robert Britton and his international team.
New work identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of harmful fats in the bloodstream. The study opens the door for the design of more specific MTP inhibitors that could reduce circulating triglyceride levels without the risk of unpleasant and serious side effects in the intestines and liver.
Researchers from Goethe University have found what is perhaps the oldest enzyme in cellular respiration. They have been able to isolate the extremely fragile 'Rnf' protein complex from the heat-loving bacterium Thermotoga maritima. In fact, the genes that encode for the enzyme were already discovered. However, the researchers have now succeeded for the first time in isolating the enzyme and thus in proving that it really is formed by bacteria and used for energy production.
Scientists in Japan designed a gate-type adsorbent tower system that captures and separates mixed gases, CO2, to enable lowering greenhouse gas emissions from industrial sources.
Researchers in Lásló Forró's lab at EPFL, Switzerland, are working on a membrane made of titanium oxide nanowires, similar in appearance to filter paper but with antibacterial and antiviral properties. Their material works by using the photocatalytic properties of titanium dioxide: when exposed to ultraviolet radiation, the fibers convert resident moisture into oxidizing agents such as hydrogen peroxide, which have the ability to destroy pathogens.
Plants recognize beneficial microbes and keep harmful ones out, which is important for healthy plants production and global food security. Scientists have now discovered how legumes use small, well-defined motifs in receptor proteins to read molecular signals produced by both pathogenic and symbiotic microbes. These remarkable findings have enabled the researchers to reprogram immune receptors into symbiotic receptors, which is the first milestone for engineering symbiotic nitrogen-fixing symbiosis into cereal crops.
Using comprehensive genetic analysis, Kumamoto University researchers have found, for the first time, that the NSD2 enzyme blocks cell aging. Inhibition of NSD2 function in normal cells leads to rapid senescence of cells and the amount of NSD2 in senescent cells is significantly reduced. It is hoped that these findings will help clarify the mechanisms of aging, the development of control methods for maintaining NSD2 functionality, and age-related pathophysiology.
Creative chemists employ enzymes to build a complex but promising natural anti-cancer agent called cepafungin I in a lean nine steps.
Sustainable flip-flops: A team of UC San Diego researchers has formulated polyurethane foams made from algae oil to meet commercial specifications for midsole shoes and the foot-bed of flip-flops. The results of their study are published in Bioresource Technology Reports and describe the team's successful development of these sustainable, consumer-ready and biodegradable materials.
Researchers at the University of Wisconsin-Madison have developed a method combining sticky nanoparticles with high-precision protein measurement to capture and analyze a common marker of heart disease to reveal details that were previously inaccessible.