Since the emergence of molecular genetics, scientists have tried to isolate haploid mammalian cells. Haploid cells are a powerful genetic tool to analyse gene function. In the past decade, a number of researchers finally succeeded in developing haploid cell line cultures. However, these cell lines are unstable and have a tendency for diploidisation. Now, researchers at the CNIO have identified chemical compounds that increase the stability of mammalian haploid cell lines.
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
Researchers find that substances synthesized from plant species endemic to the biodiversity hotspot can kill the parasites that cause these neglected diseases.
The chemical process by which bacteria break down algae into an energy source for the marine food chain, has been unknown - until now. For the first time, is has been possible to clarify the biochemical function of the multitude of enzymes involved in this process. Now it becomes possible to use algae as a resource: they can be used for fermentations, to produce valuable types of sugar or, in the future, even bioplastics.
Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude scientists have determined at atomic resolution the structure of machinery that drives the process.
Associate Professor Hamsa Puthalakath's explanation of why some cancers don't respond to treatment with one of the most effective chemotherapy drugs: 5-Fluorouracil (5-FU) has the potential to lead to: a lab test to check for 5-FU resistance, which would reduce unnecessary chemotherapy treatments; a new drug to turn off 5-FU in resistance; and he finds 5-FU resistance is linked to a the protein 'BOK,' the function of which has stumped scientists for decades.
A team led by a Baylor University researcher has published a breakthrough article that provides a better understanding of the dynamic process by which sunlight-induced DNA damage is recognized by the molecular repair machinery in cells as needing repair.
Scientists at the University of Warwick have discovered a new process that sets the fastest molecular motor on its marathon-like runs through our neurons.
Researchers from Clemson University's Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males.
A new molecular descriptor estimates molecular complexity and defines the evolution of small molecules in medicinal chemistry.