A small device, called "Smart Stirrer", performed a function of a conventional laboratory stir bar, has an integrated microprocessor and various sensors capable of wireless and autonomous report the conversion of properties of a solution. Results are sent to a computer over Bluetooth, and any changes notify the user wirelessly.
A novel mathematical modeling method has been developed to estimate operation models of biomolecular motors from single-molecule imaging data of motion with the Bayesian inference framework. The operation mechanism of a linear molecular motor "chitinase", which moves one-way on a chitin chain with degrading the chain passed by, was elucidated by mathematical modeling of experimental imaging data with the method.
Researchers from the University of Tsukuba found that the bacterium C. perfringens modulates the structure of its biofilm at different temperatures by regulating the expression of the novel extracellular protein BsaA. They showed the number of BsaA-producing cells decreases when the temperature increases from 25°C to 37°C, and BsaA-producing cells cover non-BsaA-producing cells to provide tolerance to external stresses. These findings help us understand how bacteria adapt to their environment to survive.
The tension in the membrane of cells plays an important role in a number of biological processes. A localised drop in tension makes it easier for the surface to be bending inward and form invaginations that will become free vesicles inside the cell. Are the functions of these so-called endosomes also modulated by variations in tension? Scientists have answered in the affirmative thanks to a high-precision research, using molecular probes.
University of Utah researchers find that stable isotopes in hair reveal a divergence in diet according to socioeconomic status (SES), with lower-SES areas displaying higher proportions of protein coming from cornfed animals. It's a way, the authors write, to assess a community's diet and their health risks.
Group of researchers at IOCB Prague determined and analyzed the precise structure of the Nsp16 and Nsp10 protein complex of the new coronavirus SARS-CoV-2. They identified several fundamental characteristics, which can be targeted by inhibitors that suppress the activity of the Nsp16 and Nsp10 protein complex and may, in the future, serve as drugs to combat many coronaviruses.
An international team of researchers led by Aarhus University are the first to determine the crystal structure of an exopolysaccharide receptor. The results give insight into how plants and microbes communicate, and this knowledge can hopefully be used for more sustainable agriculture where microbes play an important role.
Compounds tested for their potential as antibiotics have demonstrated promising activity against one of the deadliest infectious diseases - tuberculosis (TB).
Of the CRISPR-Cas9 tools created to date, base editors have gotten lots of attention because of their seemingly simple editing: they neatly replace one nucleic acid with another, in many cases all that should be needed to fix a genetic disease. UC Berkeley scientists have now determined the structure of the latest base editor as it swaps out nucleic acids, showing why it can go off target but also how it can be improved.
UMass Medical School scientists Jill Moore, PhD, Zhiping Weng, PhD, and MD/PhD students Michael Purcaro and Henry Pratt are lead authors on the latest publication of data from the ambitious ENCODE project to annotate the human genome.