Apolipoproten E (apoeE) is a major genetic risk factor for the development of Alzheimer's disease, yet it tends to be understudied as a potential druggable target for the mind-robbing neurodegenerative disease. Now a research team led by the University of South Florida Health (USF Health) Morsani College of Medicine reports that a novel apoE antagonist blocks apoE interaction with N-terminal amyloid precursor protein (APP) and reduces hallmark Alzheimer's-associated pathologies.
A new preclinical study by University of South Florida neuroscientists finds that anxiety-like behavior increases when early life adversity combines with high levels of FKBP5 -- a protein capable of modifying hormonal stress response. Moreover, the researchers demonstrate this genetic-early life stress interaction amplifies anxiety by selectively altering signaling of the enzyme AKT in the dorsal hippocampus, a portion of the brain primarily responsible for cognitive functions like learning and memory.
Controlling the frequency of 'brain waves' could help to improve people's recall of memories and potentially provide a key to unlock conditions such as Alzheimer's disease, according to a new article.
Experiences such as poverty, residential instability, or parental divorce or substance abuse, can affect executive function and lead to changes in a child's brain chemistry, muting the effects of stress hormones, according to a new University of Washington study.
Research at the University of York has shown that women are underrepresented in research into links between cannabis and psychosis, which could limit understanding of the impact of the drug.
We know bees get the concept of zero and can do basic math. Now researchers have discovered they may also be capable of connecting symbols to numbers. It's a finding that sheds new light on how numerical abilities may have evolved over millennia and even opens new possibilities for communication between humans and other species.
Nearly half the amplitude typically used in standard electroconvulsive therapy (ECT) seems to be effective at treating suicidal thoughts, investigators report.
Scientists at UC San Francisco have developed a personalized digital meditation training program that significantly improved attention and memory in healthy young adults -- a group already at the peak of brain health -- in just six weeks.
A study by UCLA psychologists provides strong evidence that a certain region of the brain plays a critical role in memory recall. The research, published in the Journal of Cognitive Neuroscience, also shows for the first time that using an electrical current to stimulate that region, the left rostrolateral prefrontal cortex, improves people's ability to retrieve memories.
Researchers have long known that racism is linked to health problems, but now results from a small study using RNA tests show that racism appears to increase chronic inflammation among African Americans.