Yuyu Song of Harvard Medical School was a Grass Fellow at the Marine Biological Laboratory (MBL) when she took advantage of a powerful research organism in neuroscience, the local squid, to start asking how a mutant protein associated with familial ALS behaves under controlled conditions. Her study, recently published in eNeuro, clarifies the mechanisms underlying neural dysfunction in ALS, and also suggests a novel approach to restoring the health of motor neurons in patients with the disease.
Using TPD technology, CeMM researchers set out to understand set out to understand the primary role of a key regulator of transcription, the human Mediator complex. The recent study by Georg Winter's group discovered that Mediator particularly safeguards the transcription of a small set of cell-type-specifying genes. In collaboration with Patrick Cramer's lab at the MPI for Biophysical Chemistry, the scientists revealed mechanistic details of how Mediator enables cells to robustly exert their dedicated functions.
EPFL scientists have developed FloChip, a new microfluidic take on the widely used chromatin immunoprecipitation (ChIP) technique. By automating and cutting the cost of ChIP and sequential-ChIP, FloChIP has the potential to become a widely used tool for the study of chromatin biology and gene regulation.
A Kobe University research group has successfully created 3D fluorescence and phase imaging of living cells based on digital holography. This technology will form a foundation for living cell imaging, which is indispensable in the life sciences field. It is also expected that using this technology to visualize stem cell processes in plants will increase our understanding of them.
A new study released in STEM CELLS sorts through the maze of contradictions to finally determine that the multiple roles of p53 in cell cycle regulation and apoptosis are acquired during pluripotent stem cell differentiation.
A new study published today in Neuron led by The New York Stem Cell Foundation (NYSCF) Research Institute's Valentina Fossati, Ph.D., creates astrocytes - an integral support cell in the brain -- from stem cells and shows that in disease-like environments, these normally helpful cells can turn into neuron-killers.
How does general anesthesia cause loss of consciousness? Despite its 175-year-history of use by the U.S. medical system, science has been unable to definitively answer that question, until now. The lipid-based answer could open other brain mysteries.
Watching and measuring what happens in tissues inside the human embryo is currently not possible, and it's difficult to do in mammalian models. Because humans and the fruit fly Drosophila share so many biological similarities, Columbia Engineering and Syracuse University researchers tackled this problem by focusing on fruit flies. The team reports today that they can predict when the tissue will begin to rapidly flow just by looking at cell shapes in the tissue.
A team of scientists at the Sloan Kettering Institute has discovered how the X and Y chromosomes find one another, break, and recombine during meiosis even though they have little in common.
A University of Pennsylvania-led team used an inhibitor of an enzyme called p38α kinase to suppress the spread of melanoma to the lungs in a mouse model.