Researchers in the lab of Joslin's Yu-Hua Tseng, PhD, a Senior Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center, have discovered an unexpected biological pathway by which brown fat cells can translate energy into heat.
As the world grapples with the COVID-19 pandemic, a new mathematical model could offer insights on how to improve future epidemic predictions based on how information mutates as it is transmitted from person to person and group to group. The Army Research Office funded this model, developed by researchers at Carnegie Mellon University and Princeton University.
NTU Singapore scientists have created a paper-like material derived from pollen that bends and curls in response to changing levels of environmental humidity. The ability of this paper made from pollen to alter its mechanical characteristics in response to external stimuli may make it useful in a wide range of applications, from artificial muscles to sensors. Combined with digital printing, it may hold promise for the fabrication of a new generation of programmable natural actuators.
The movements of cell muscles in the form of tiny filaments of proteins have been visualized at unprecedented detail by University of Warwick scientists.
New research from the Cancer Science Institute of Singapore at the National University of Singapore revealed a genetic variant in a gene called MET that is responsible for more aggressive growth of head and neck, and lung cancers in Asian populations.
Some insect wings such as cicada and dragonfly possess nanopillar structures that kill bacteria upon contact. However, to date, the precise mechanisms that cause bacterial death have been unknown. Using a range of advanced imaging tools, functional assays and proteomic analyses, a study by the University of Bristol has identified new ways in which nanopillars can damage bacteria.
Patients with colon cancer, but no distant metastases, can benefit from a short course of immunotherapy while waiting for their surgery, as it can cause tumours to shrink substantially or clear up in a very short time. This is the finding of the phase II NICHE study led by Myriam Chalabi from the Netherlands Cancer Institute. In patients with the MSI subtype (MSI) the response rate was 100%. In the MSS subtype, this WAS 25%.
With the goal of ensuring that single-cell RNA sequencing, a current focus of intense research, makes use of the best possible methods, an international group has benchmarked 13 different methods. The group, led by Holger Heyn of the Centro Nacional de Análisis Genómico (CNAG-CRG) in Spain, found that the Quartz-seq2 method, developed by a team in the RIKEN Center for Biosystems Dynamics Research, was overall the best method developed to sequence single-cell RNA.
Unprovoked recurrent seizures are a serious problem affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Fralin Biomedical Research Institute researchers tested the hypothesis that glioma-induces processes that renders a type of brain cells dysfunctional, perpetuating the imbalance between excitation and inhibition in tumor-associated epilepsy.
A targeted therapy, currently being studied for treatment of certain cancers including glioblastoma, may also be beneficial in treating other neurologic diseases, a study at the University of Cincinnati shows.