University of Iowa biologists have learned animals can alert future offspring of dangers they will encounter when born. In studies with roundworms and mouse cells, researchers showed how mothers pass chemical signals to their unfertilized eggs, where the warning is stored in the egg cells and passed to offspring after birth.
The immune system's ability to marshal specialized cells to fight off infection relies in part on tiny molecules called microRNAs, which act as a release for the 'brakes' that keep cells dormant until needed, according to a new study published in the journal Cell Reports.
Patients infected with either severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 produce antibodies that bind to the other coronavirus, but the cross-reactive antibodies are not cross protective, at least in cell-culture experiments, researchers report May 17 in the journal Cell Reports. It remains unclear whether such antibodies offer cross protection in the human body or potentiate disease.
EPFL scientists have uncovered the molecular biology behind Hyaline Fibromatosis Syndrome, a severe genetic disease.
Fibroblasts present in different pancreatic diseases are genetically distinct and their functions are 'programmed' by the unique environment of each disease, according to new research from the University of Liverpool (UK).
Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells. The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.
By coupling a bacterial injection system with a light-controlled molecular switch, scientists are able to inject proteins into eukaryontic cells
Research at Kanazawa University, Theragen Etex Bio Institute and Seoul National University as reported in Nature Communications points towards pathways for the metastasis and malignant transitions that result from changes in the protein p53. The results suggest that the cooperative development of mutations in the proteins helps tumors spread and metastasis.
Cats are twice as likely to survive a venomous snakebite than dogs, and the reasons behind this strange phenomenon have been revealed by University of Queensland research. The research team, led by Ph.D. student Christina Zdenek and Associate Professor Bryan Fry, compared the effects of snake venoms on the blood clotting agents in dogs and cats, hoping to help save the lives of our furry friends.
A new study led by Marc Veldhoen, group leader at Instituto de Medicina Molecular and published this week in the prestigious Nature Immunology, shows that the local availability of specific molecules is crucial to generate these tissue resident surveillance cells. The impact of these results extends beyond protective immunity in tissues, as these cells are also efficient when elicited after vaccination and yield more effective anti-tumor immunity.