Researchers from the University of Colorado School of Medicine have identified a new way that cells in the central nervous system regenerate and repair following damage. In an article published in the current issue of Nature Neuroscience, scientists from CU found that precisely-timed motor learning stimulates cellular processes to improve recovery after damage to oligodendrocytes, cells that are critical for healthy neurologic function throughout life.
Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells. The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.
By coupling a bacterial injection system with a light-controlled molecular switch, scientists are able to inject proteins into eukaryontic cells
Research at Kanazawa University, Theragen Etex Bio Institute and Seoul National University as reported in Nature Communications points towards pathways for the metastasis and malignant transitions that result from changes in the protein p53. The results suggest that the cooperative development of mutations in the proteins helps tumors spread and metastasis.
Cats are twice as likely to survive a venomous snakebite than dogs, and the reasons behind this strange phenomenon have been revealed by University of Queensland research. The research team, led by Ph.D. student Christina Zdenek and Associate Professor Bryan Fry, compared the effects of snake venoms on the blood clotting agents in dogs and cats, hoping to help save the lives of our furry friends.
A new study led by Marc Veldhoen, group leader at Instituto de Medicina Molecular and published this week in the prestigious Nature Immunology, shows that the local availability of specific molecules is crucial to generate these tissue resident surveillance cells. The impact of these results extends beyond protective immunity in tissues, as these cells are also efficient when elicited after vaccination and yield more effective anti-tumor immunity.
Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy.
The results of a clinical trial released today in STEM CELLS Translational Medicine demonstrate how a topical solution made up of stem cells leads to the regrowth of hair for people with a common type of baldness.
A Duke University research team has found a small area of the brain in mice that can profoundly control the animals' sense of pain. Somewhat unexpectedly, this brain center turns pain off, not on. It's located in an area where few people would have thought to look for an anti-pain center, the amygdala, which is often considered the home of negative emotions and responses, like the fight or flight response and general anxiety.
It's not just the presence of bacteria that can lead to disease; their spatial arrangement also matters. When University of Pennsylvania and Georgia Tech scientists examined the bacteria that causes tooth decay, they found it 'shields' itself under blankets of sugars and other bacteria in a crown-like arrangement, helping it evade antimicrobials and concentrate its tooth-damaging acids.