Researchers have developed the first computational model of a human cell and simulated its behavior for 15 minutes -- the longest time achieved for a biological system of this complexity. In a new study, simulations reveal the effects of spatial organization within cells on some of the genetic processes that control the regulation and development of human traits and some human diseases.
The giant cavity, in a protein that transports nutrients across the cell membrane, is unlike anything researchers have seen before.
Magnetic bacteria might soon be used for the production of novel biomaterials. A team of microbiologists at the University of Bayreuth led by Prof. Dr. Dirk Schüler developed a modular system for the genetic reprogramming of bacteria, thereby turning the organisms into cell factories for multifunctional magnetic nanoparticles that combine various useful functions and properties.
Changes in a specific type of sugarlike molecule, or glycan, on the surface of cancer cells help them to spread into other tissues, according to researchers at UC Davis.
Researchers at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) have developed a device that moves fluids over corneal cells similarly to the movement of tears over a blinking eye. The scientists hope their findings, reported in the journal Lab on a Chip, will help improve ophthalmic drug development and testing, and advance understanding of how blinking affects the corneal surface.
Researchers from Osaka University developed and validated a novel PITX2-eGFP hiPSC reporter line to model the development of periocular mesenchymal cells. These findings could help understand how the eye develops during embryogenesis and how it changes during disease processes.
Discovery of an entirely new source of cancer cell diversity has profound implications for cancer research and treatment, research from the University of Sydney has found.
Cancer is a leading cause of death worldwide. When caught in its early stages, before metastasis (which is the growth of a secondary tumor separate to the primary site of cancer), it is known that cancer survival rates are higher. NYUAD researchers have developed a new fluid analyzing platform that allows for the isolation of circulating tumor cells (CTCs), which are formed during metastasis. The new technology, featured in the Nature journal Microsystems and Nanoengineering,
Organellogenesis, where an endosymbiont is transformed into an organelle within the host, is not well understood. In a recent study, researchers led by the University of Tsukuba identified two novel dinoflagellates containing relic endosymbionts along with their nuclei and showed that endosymbiont-host DNA transfer was still in progress. Because the process is incomplete in these strains, the researchers hope they can be used to shed light on the genomic changes that occur during organellogenesis.
University of Tsukuba researchers identified neurons that promote non-REM sleep in the brainstem in mice. These neurons commonly expressed the gene that encodes the neuropeptide neurotensin. Activation of these neurons induced non-REM sleep. Moreover, direct administration of neurotensin into the ventricle induced NREM sleep-like brain activity. These findings contribute to our understanding of sleep promotion and sleep disorders, and could tell us more about the evolution of sleep architecture in mammals.