A drug known as SP-2577 could help enable the body's own immune system to attack ovarian cancer, according to a study led by TGen. Published today in the scientific journal PLOS ONE, the study builds on years of research led by Dr. Jeffrey Trent, TGen President and Research Director, into a type of ovarian cancer known as Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT), a cancer that usually strikes girls and young women.
Researchers at Baylor College of Medicine and Texas Children's Hospital have developed a novel noninvasive approach called nano-radiomics that analyzes imaging data to assess changes in the tumor microenvironment that are not detected with conventional imaging methods.
Thin film coatings do more than add color to walls. For example, they can be used as pharmaceutical devices. How these coatings dry can change their properties, which is especially important for films used in drug delivery. Lehigh University engineering researchers studying the in situ drying behavior of thin film coatings are visualizing particle interactions with groundbreaking precision. Their findings could impact the development of drug delivery technology.
A study investigating sustainable-origin sorbent materials to clean up oil spill disasters has made a surprising discovery. Dog fur is particularly good at cleaning up crude oil from different types of land surfaces and, together with human hair recycled from salons, can be used as an effective and sustainable way to mop dangerous environmental contaminants.
Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.
Researchers at MIT and Brigham and Women's Hospital have designed a new silicone rubber face mask that they believe could stop viral particles as effectively as N95 masks. Unlike N95 masks, the new masks can be easily sterilized and used many times.
Pesticides, pharmaceutical products, and endocrine disruptors are some of the emerging contaminants often found in treated domestic wastewater, even after secondary treatment. Professor Patrick Drogui of the Institut national de la recherche scientifique (INRS) and his team have tested the effectiveness of a tertiary treatment process using electricity in partnership with the European Membrane Institute in Montpellier (IEM) and Université Paris-Est.
The CRISPR system is a powerful tool for the targeted editing of genomes, with significant therapeutic potential, but runs the risk of inappropriately editing "off-target" sites. However, a new study publishing July 9, 2020 in the open-access journal PLOS Biology by Feng Gu of Wenzhou Medical University, China, and colleagues, shows that mutating the enzyme at the heart of the CRISPR gene editing system can improve its fidelity.
This is one of the first comprehensive looks at lung cells using a technology called single-cell RNA sequencing. Instead of examining a mash-up of many cells from a tissue sample, single-cell sequencing allowed researchers in this study to closely examine the individual cells that make up the lungs; to identify their function, and ultimately understand the molecular changes that may be driving the disease.
The discovery of green fluorescent protein (GFP), which is made by a jellyfish, transformed cell biology. It allowed scientists to stitch the GFP sequence to proteins from other organisms to trace their movements and interactions in living cells. Now, researchers reporting in ACS Applied Materials & Interfaces have designed peptide nanoparticles that can each glow in a variety of colors, opening the door for many new biomedical applications.