Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. To improve that survival rate, researchers at The University of Texas at San Antonio (UTSA) and the University of Texas MD Anderson Cancer Center created an online atlas to identify and classify protein signatures present at AML diagnosis.
A University of Waterloo researcher has spearheaded the development of a software tool that can provide conclusive answers to some of the world's most fascinating questions.
A Harvard Medical School scientist has used a form of artificial intelligence known as deep learning to predict the 3D structure of effectively any protein based on its amino acid sequence. This new approach for computationally determining protein structure achieves accuracy comparable to current state-of-the-art methods but at speeds upward of a million times faster.
The Critical Path Institute (C-Path) and CDISC are pleased to announce the release of a global Therapeutic Area Standard that specifies how to structure commonly collected data and outcome measurements in clinical trials for HIV. The standard, released in the form of User Guide for data managers, statisticians, programmers and study managers, covers the areas of prevention, vaccines and treatment and is freely available on the CDISC website.
Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which include additions, deletions and rearrangements of large segments of DNA. A recent study used multiple advanced technologies to dive deeper than ever before to comprehensively characterize the structural variants present in three families, and what their functional consequences might be.
The lamprey, an eel-like primitive vertebrate, is a popular organism for neurobiology studies because it has a relatively simple nervous system. It is of particular interest to those studying spinal cord injury because, unlike humans, the lamprey can regenerate nerve connections and recover normal mobility within about 8 weeks following an injury to its spinal cord.
In the quest to separate the good traits from the bad, bioinformatics (computational biology) research at the Earlham Institute (EI), using a data driven strategy in wheat, find the first ever gene associated with gene conversion in plants -- marking an important step in global initiative Designing Future Wheat.
A research team featuring bioinformaticians from the Moscow Institute of Physics and Technology (MIPT) has identified reliable markers of gene activity. The discovery has potential for future applications in clinical practice. The findings are reported in BMC Genomics.
Originally adapted in 2017, CUT&RUN has since been successfully applied to populations of more than 1,000 cells. Hainer and Fazzio sought to further adapt this technology and in this paper describe, for the first time, the genome-wide mapping of factor occupancy from single cells and individual pre-implantation mouse embryos
Until now it was difficult to answer this question, as a good benchmark for testing these bioinformatics programs was lacking. AU scientists, Dr. Jakob T. Nielsen and Dr. Frans A.A. Mulder present an analysis in Scientific Reports using a comprehensive compilation of experimental data from NMR spectroscopy.