Genomics fails to diagnose up to half of patients who are tested. German scientists tackled the problem in a recent study in the journal Molecular & Cellular Proteomics. Using a new neutrophil proteome database they made genetic diagnoses for children with severe congenital neutropenia whom typical sequencing had failed.
George Mason University's Yuntao Wu's research team has identified a measurable indicator that could prove instrumental in the fight against HIV. The research recently published in Science Advances, focuses on cofilin, a key protein that regulates cells to mobilize and fight against infection. HIV patients have "significantly lower" levels of cofilin phosphorylation--but by stimulating the T cells with additional therapeutics, researchers could modulate the levels of cofilin activity needed to restore T cell mobility.
Certara recognized several years ago that model-informed drug development could also provide tremendous value if used by healthcare providers to determine the optimal drug dose for individual patients in the clinic. Certara scientists have been engaged in critical assessments of hurdles to model-informed precision dosing (MIPD) and have published four new papers in the past months delineating the vision and practical path(s) for making individualized dosing a reality under the efforts for 'Precision Medicine.'
A new study has revealed how a group of deep-sea microbes provides clues to the evolution of life on Earth, according to a recent paper in The ISME Journal. Researchers used cutting-edge molecular methods to study these microbes, which thrive in the hot, oxygen-free fluids that flow through Earth's crust.
A team of researchers from Bar-Ilan University has developed a computational tool for analyzing genetic changes related to the immune system. With this new development, the onset of many autoimmune diseases, such as multiple sclerosis and celiac disease, infectious diseases, such as hepatitis C and flu, and various forms of cancer may be predicted.
Discovering that your new designer handbag or gold watch is a fake is costly and annoying, and counterfeit medical devices or drugs could have even more serious consequences. But seemingly as soon as manufacturers develop a new method to ensure product authenticity, counterfeiters find a way to outsmart it. Now, researchers have created an 'unclonable' tag that can never be replicated, even by the manufacturer. They report their results in ACS Applied Materials & Interfaces.
New research reveals that biodiversity 'hotspots' in the tropics produced new species at faster rates over the last 25 million years, but those in temperate regions are instead full of migrant species that likely sought refuge from shifting and cooling climates.
A research team has described the first case of a patient affected by dysfunctions in a nucleoside transporter of the SLC28 gene family, which brings a set of genes which were not related to human pathologies in the scientific bibliography so far.
Researchers at Osaka University, the University of Tokyo, RIKEN, and others performed a meta-analysis using data on over 36,000 Japanese sufferers of type 2 diabetes (T2D) from four genome-wide association studies to identify genetic factors linked to this disease. Findings revealed 88 associated genomic loci, including 28 novel ones. Several mutations linked to T2D for the Japanese population in this study are absent from Europeans, suggesting the potential for Japanese- or Asian-specific treatments of T2D.
Microbes are the most common and diverse organisms on the planet. A new search engine, called BIGSI, allows scientists to search public microbial DNA data for specific genes and mutations. This could help researchers monitor the spread of antibiotic resistance genes, and understand how bacteria and viruses evolve and adapt.