Using single-molecule imaging, researchers witness how molecules find and fix damaged DNA.
Some parasitic plants steal genetic material from their host plants and use the stolen genes to more effectively siphon off the host's nutrients. A new study led by researchers at Penn State and Virginia Tech reveals that the parasitic plant dodder has stolen a large amount of genetic material from its hosts, including over 100 functional genes, through a process called horizontal gene transfer.
Four different rare diseases are all caused by the same short segment of DNA repeated too many times, a mutation researchers call noncoding expanded tandem repeats. Researchers suspect variations of this type of mutation may cause other diseases that have thus far evaded diagnosis by genetic testing. Researchers are excited because instead of finding unique mutations in specific genes, they identified the same mutation in different areas of the genome causing different diseases.
Researchers at NHGRI have performed the largest GWAS study on type 2 diabetes in the sub-Saharan African populations, revealing an association between the disease and previously unlinked ZRANB3 gene. By using animal models, their results show that dysfunction of the ZRANB3 gene has major repercussions on insulin production. This link may hold key answers to the treatment of type 2 diabetes in all populations.
KAIST researchers have identified somatic mutations in the brain that could contribute to the development of Alzheimer's disease (AD).
An international Research Team led by Dr. Jeong Yoon-ha at Korea Brain Research Institute has published the results of its research in 'Autophagy'. Expected to develop the treatment for neurodegenerative disease utilizing TDP-43 protein.
Low doses of radiation equivalent to three CT scans, which are considered safe, give cancer-capable cells a competitive advantage over normal cells. Researchers studied the effects of low doses of radiation in mice and found it increases the number of cells with mutations in p53, a well-known genetic change associated with cancer. However, giving the mice an antioxidant before radiation promoted the growth of healthy cells, which outcompeted and replaced the p53 mutant cells.
Under physiological conditions, only certain sequences within the genome, called flipons, are capable of dynamically forming either right- or left-handed DNA. When a flipon is left-handed, genes change the transcripts they produce, affecting how cells respond to their environment. The outcomes depend on both the shape and sequence of a gene's DNA, each feature encoding a different subset of genetic information: one dynamic, the other static. Both flipons and codons are subject to natural selection.
Waterhemp and Palmer amaranth, two aggressive weeds that threaten the food supply in North America, are increasingly hard to kill with commercially available herbicides. A novel approach known as genetic control could one day reduce the need for these chemicals. Now, scientists are one step closer.
Synthetic biologists seek to create new life with forms and functions not seen in nature. Although scientists are a long way from making a completely artificial life form, they have made semi-synthetic organisms that have an expanded genetic code, allowing them to produce never-before-seen proteins. Now, researchers reporting in Journal of the American Chemical Society have optimized a semi-synthetic bacteria to efficiently produce proteins containing unnatural amino acids.