Targeted drugs for breast and lung cancer could be used together to overcome resistance to treatment in several different tumour types, a new study shows. Scientists discovered that when the breast cancer drug palbociclib was combined with the lung cancer drug crizotinib, the two-drug combination was significantly more effective against cancer cells in the laboratory than either drug used on its own.
The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.
Researchers have now found a new way to extract useful information out of sequenced DNA. By cataloging subtle evolutionary signatures shared between pairs of genes in bacteria, the team discovered hundreds of previously unknown protein interactions. This method is now being applied to the human genome to seek new insights into how our proteins interact.
Hidden underground networks of plant roots snake through the earth foraging for nutrients and water, similar to a worm searching for food. Yet, the genetic and molecular mechanisms that govern which parts of the soil roots explore remain largely unknown. Now, Salk Institute researchers have discovered a gene that determines whether roots grow deep or shallow in the soil.
The cellular composition of the liver is incompletely understood. Researchers at the Max Planck Institute for Immunobiology and Epigenetics have created a comprehensive map of all cell types in the healthy human liver using a method named single-cell RNA sequencing. They discovered new subpopulations of liver cell types and demonstrated the usefulness of their human liver cell atlas as a resource to reveal how cells change in liver cancer. The study was published in Nature.
Adults with a first-degree relative with Alzheimer's disease perform more poorly on online paired-learning tasks than adults without such a family history, and this impairment appears to be exacerbated by having diabetes or a genetic variation in the apolipoprotein E (APOE) gene linked to the disease.
Researchers are hopeful that new strategies could emerge for slowing the growth and recurrence of the most common primary brain cancer in adults, glioblastoma, based on the results of a study published today in Cancer Research.
A newly described form of stress called chromatin architectural defect, or chromatin stress, triggers in cells a response that leads to a longer life.
Hox gene do not work alone to determine the layout of vertebrae, limbs and other body parts. A study led by University of Pittsburgh researchers shows how an entire network works together toward that goal.
Japanese scientists at Toho University in Tokyo discovered a new mechanism to generate regulatory T cells (Treg cells), lymphocytes preventing autoimmunity and excess immune responses. They found that a gene called JunB mediates signaling of the cytokine interleukin-2 (IL-2) to facilitate generation of Treg cells, raising the possibility that JunB might be a target to expand Treg cells.