ECCITE-seq (Expanded CRISPR-compatible Cellular Indexing of Transcriptomes and Epitopes by sequencing), developed by scientists at the New York Genome Center's Technology Innovation Lab, allows researchers to perform high-throughput measurements of multiple modalities of information from single cells. The technique, published today in Nature Methods, profiles different types of biomolecules from thousands of single cells in parallel, offering a breadth of information that can be used as readout in CRISPR-based pooled genetics screens.
A new study reveals the surprising way that family quarrels in seeds drive rapid evolution. Researchers discovered that conflict over the amount of resources an offspring receives from its parent seems to play a special role in the development of certain seed tissues.
Far Eastern Federal University (FEFU) scientists teamed up with colleagues from the UK and Mauritius and experimentally demonstrated that extracts of the endemic (i.e. growing only on this island) medicinal herb leaves Acalypha integrifolia, Eugenia tinifolia, and Labourdonnaisia glauca stop the proliferation of esophageal squamous carcinoma cells, ones of the most deadly cancer type worldwide. A related article is published in the Acta Naturae journal.
NTU Singapore scientists have developed a sustainable way to demonstrate a new genetic modification that can increase the yield of natural oil in seeds by up to 15% in laboratory conditions.
What will a three-degree-warmer world look like? When experiencing stress or damage from various sources, plants use chloroplast-to-nucleus communication to regulate gene expression and help them cope. Now, Salk Institute researchers have found that GUN1 -- a gene that integrates numerous chloroplast-to-nucleus retrograde signaling pathways -- also plays an important role in how proteins are made in damaged chloroplasts, which provides a new insight into how plants respond to stress.
Named after the dark stripes that form inside potatoes after they are cut and fried, zebra chip disease is a potentially devastating affliction that can result in yield losses up to 100% for farmers. Swisher et al. identified a new haplotype, designated haplotype F, that causes zebra chip symptoms in potato. Prior to this discovery, 'only haplotypes A and B were known to cause zebra chip symptoms in potato,' explains Swisher.
In a new study, Northwestern University researchers tested bacteria commonly found inside homes on samples of drywall coated with antimicrobial, synthetic latex paints. Within 24 hours, all bacteria died except for Bacillus timonensis, a spore-forming bacterium.
Scientists from Lancaster University have discovered that immune responses originally found to prevent fungal infections are also important in eliminating Trichinella spiralis, a round worm and the causative agent of Trichinosis. People acquire trichinellosis by consuming raw or undercooked meat infected with the Trichinella parasite, particularly wild game meat or pork.
Whether a wound -- such as a diabetic foot ulcer -- heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
New research sheds light on how a hepatitis B viral protein stimulates the expansion of immune cells that impair antiviral responses, according to a study published April 18 in the open-access journal PLOS Pathogens by Haitao Guo of the Indiana University School of Medicine, Bin Wang and Jiming Zhang of Fudan University, and colleagues. The findings potentially explain how the hepatitis B virus (HBV) establishes and maintains chronic infection, and could lead to the development of novel therapeutic strategies.