Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application.This review presents an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery systems.
Vinorelbine bitartrate (VRL), a semi synthetic vinca alkaloid approved for breast cancer, has been proven to be beneficial as first line and subsequent therapies. However, its hydrophilic and thermo labile nature provides hindrance to oral clinical translation. The current work focused on the application of DOE a modern statistical optimization tool for the development and optimization of a solid lipid nanoparticle (SLN) formulation that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate (VRL) to a maximum extent without compromising integrity and anticancer activity of the drug.
Astronomers have captured one of the most detailed views of a young star taken to date, and revealed an unexpected companion in orbit around it.
2019 will be, as proclaimed by the UN, the 'International Year of the Periodic Table of Chemical Elements', in commemoration of the 150th anniversary of its creation. Researchers from the Faculty of Science of the University of Malaga (UMA) have recently revealed new properties of one of its key elements: sulfur.
When humans experience stress, their inner turmoil may not be apparent to an outside observer. But many animals deal with stressful circumstances -- overcrowded conditions, not enough food -- by completely remodeling their bodies. These stress-induced forms, whether they offer a protective covering or more camouflaged coloration, can better withstand the challenge and help the animal survive until conditions improve.
In 1994, Chinese university student Zhu Ling began experiencing stomach pain, hair loss and partial paralysis. By the time doctors diagnosed Ling with thallium poisoning about four months later, she was in a coma. Two decades after the poisoning, Richard Ash--an associate research scientist in the University of Maryland's Department of Geology--used mass spectrometry to analyze several of Ling's hairs collected in 1994 and 1995 and established a timeline of her poisoning.
Now, astronomers have used Hubble to nab a second 'very warm' Neptune (GJ 3470b) that is losing its atmosphere at a rate 100 times faster than that of GJ 436b. Both planets reside about 3.7 million miles from their star. That's one-tenth the distance between our solar system's innermost planet, Mercury, and the Sun.
Slimy, hard-to-clean bacterial mats called biofilms cause problems ranging from medical infections to clogged drains and fouled industrial equipment. Now, researchers at Princeton have found a way to cleanly and completely peel off these notorious sludges.
Researchers have combined artificial neural networks with infrared thermal imaging to control and interpret chemical reactions with new precision and speed. Novel microreactors allow chemical discoveries to take place quickly and with far less environmental waste than standard large-scale reactions. The system can reduce the decision-making process about certain chemical manufacturing processes from one year to a matter of weeks, saving tons of chemical waste and energy in the process.
Brain scientists have plenty of ways to track the activity of individual neurons in the brain, but they're all invasive. Now, Stanford researchers have found a way to literally watch neurons fire -- no electrodes or chemical modifications required.