A subgroup of patients with osteosarcoma -- a form of bone cancer -- could be helped by an existing drug, suggest scientists from the Wellcome Trust Sanger Institute and their collaborators. In the largest genetic sequencing study of osteosarcoma to date, scientists discovered that 10 percent of patients with a genetic mutation in particular growth factor signalling genes may benefit from existing drugs, known as IGF1R inhibitors.
Peroxisomal biogenesis disorder, which has been linked only to lipid metabolism, is also associated with sugar metabolism.
An international team that just conducted the largest study of Tourette Syndrome has identified genetic abnormalities that are the first definitive risk genes for the disorder.
For the first time, scientists have visualized the fine details of bacterial microcompartment shells -- the organisms' submicroscopic nanoreactors, which are comprised completely of protein.
An adult mouse model reveals that changes in lattice-like structures in the brain known as perineuronal nets are necessary to 'capture' an auditory fear association and 'haul' it in as a longer-term memory.
It's a tiny marine invertebrate, no more than 3 millimeters in size. But closely related to humans, Botryllus schlosseri might hold the key to new treatments for cancer and a host of vascular diseases.
In a study published in Current Biology on June 22, the lab of Professor John Werren at the University of Rochester describes how four closely related species of parasitic wasps change their venoms rapidly in order to adapt to new hosts, and proposes that co-option of single copy genes may be a common but relatively understudied mechanism of evolution for new gene functions, particularly under conditions of rapid evolutionary change.
The elusive American pine marten, a little-studied member of the weasel family, might be more diverse than originally thought, according to new research published by a University of Montana professor.
Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded. Areas which could benefit include cancer treatment and regenerative medicine.
Snakes exhibit incredible evolutionary adaptations, including the ability to rapidly regenerate their organs and produce venom. The Castoe group at the University of Texas at Arlington studied these adaptations using genetic sequencing and advanced computing. Supercomputers of the Texas Advanced Computing Center helped the team identify a number of genes associated with organ growth in Burmese pythons, study secondary contact in related rattlesnake species, and develop tools to recognize evolutionary changes caused by natural selection.