Nagoya University research developed a high-speed cell sorting method of large cells with high-viability using dual on-chip pumps. The microfluidic chip has three-branched microchannels. Target cells are sorted into one of two interest channels by the high-speed flow produced by the on-chip pumps, while non-target cells enter a waste channel without pump actuation. The technique overcomes the limitation of many on-chip cell sorting methods in achieving the sorting of large cells at a high throughput.
A brain penetrant drug -- a small-molecule mimetic of BDNF, or brain derived neurotrophic factor -- is able to improve brain performance in Rett syndrome mice -- specifically synaptic plasticity in the hippocampus and object location memory. The hippocampus is involved in learning and memory. The drug also increased the distance mice traveled in an open field test, a measure of general locomotor activity, to normal levels.
A study by MIT researchers shows that collections of ultracold molecules can retain the information stored in them for hundreds of times longer than previously achieved in these materials. These clusters might thus serve as 'qubits,' the basic building blocks of quantum computers.
Delirium is common in elderly hospitalized patients, affecting an estimated 14-56 percent of patients. It frequently manifests as a sudden change in behavior, with patients suffering acute confusion, inattention, disorganized thinking and fluctuating mental status.
Computer simulations of electrical charges sent to retinal implants based on fractal geometry have University of Oregon researchers moving forward with their eyes focused on biological testing.
The Lung Cancer Mutation Consortium at the University of Colorado Cancer Center reports this week in the journal Cancer that 24 of 920 patients (3 percent) with advanced-stage lung cancer had mutations in the gene HER2.
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study. Research led by scientists at the University of Alberta found that irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that in normal circumstances promotes healing, but in cases of cancer, enables the cancer cells to survive. The team is now seeking a way to counteract the effect.
Researchers funded by NIH have developed an imaging method that reveals a much more diverse and flexible DNA-protein chromatin chain than previously thought. The result suggests a nimbler structure to regulate gene expression, and provide a mechanism for chemical modifications of DNA to be maintained as cells divide.
Biochar could reduce local air pollution from agriculture by reducing emissions of nitric oxide from soil. Rice University researchers argue that a better understanding of nitric oxide response to biochar will save lives and money, especially on farms near urban areas where agricultural emissions contribute to ozone and particulate matter formation.
The pioneering application of modularity analyses in archaeology yields a powerful method for highly accurate mapping of social interaction in the human past.