Solid fuels used for cooking are the prevailing source of indoor pollution in developing countries. Now a worldwide ecological assessment has found that rates of pneumonia among young children in different countries are linked with the use of solid fuels.
A new article suggests that an enzyme deficiency seen in the lysosomal storage disorder Krabbe's disease may point to new and contributing mechanisms underlying certain late-onset neurodegenerative diseases such as Parkinson's disease.
New research from the University of Liverpool highlights problems impacting on the cognitive development of children in sub-Saharan Africa.
Cisplatin is one of the most widely used agents in cancer chemotherapy. It cross-links DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team have now set up a universal, genome-wide assay to detect the specific cisplatin action sites. In the journal Angewandte Chemie they report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.
Incentives intended to stimulate the development of more treatments for rare diseases are being exploited to boost the profits of pharmaceutical companies, new research led by Bangor University shows.
Two new papers published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) reveal the importance of both the amount and timing of physical activity in reducing the risk of developing type 2 diabetes (T2D), as well as aiding the management of the disease in existing T2D patients.
In type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have now reported in the journal 'PNAS' about a mechanism used by the immune system to prepare for this attack. They were able to inhibit this process through targeted intervention and are now hoping this will lead to new possibilities for treatment.
Pathogen epitopes are fragments of bacterial or viral proteins. Nearly a third of all existing human epitopes consist of two different fragments. Known as 'spliced epitopes', these types of epitopes have long been regarded as rare. The fact that they are so highly prevalent might, among other things, explain why the immune system is so highly flexible. Results from this study have been published in the current issue of the journal Science.*
A Danish research team has developed a new method for studying how a tracer is distributed in a cancer tumor via its extensive vascular network. The method can be used for studying closely the effect of medical treatment using cancer inhibitors.
Pancreatic cancer is one of the most lethal forms of cancer. Early detection is essential to improve prognoses. Working toward that goal, a collaboration of researchers in Japan has discovered proteins in the blood which improve the detection of pancreatic cancer. When used in combination with conventional pancreatic cancer biomarkers, it enables the diagnosis of early stage pancreatic cancer, which was previously thought to be difficult.