Using a homemade, high-tech microscope, scientists have revealed how a cancer-causing virus anchors itself to our DNA. That discovery could pave the way for doctors to cure incurable diseases by flushing out viruses, including HPV and Epstein-Barr, that now permanently embed themselves in our cells.
Gene editing of bone marrow stem cells in pigtail macaques infected with simian/human immunodeficiency virus (SHIV) significantly reduces the size of dormant 'viral reservoirs' that pose a risk of reactivation. Christopher Peterson of the Fred Hutchinson Cancer Research Center in Seattle, Wash., and colleagues present these findings in PLOS Pathogens.
Of the genetically diverse population of HIV-1 viruses present in an infected pregnant woman, the few she might transmit to her child during delivery are resistant to attack by antibodies in her blood, according to new research published in PLOS Pathogens by Amit Kumar of Duke University Medical Centre, North Carolina, and colleagues.
Quebecers do not have equal access to anti-retroviral treatment (ART) for HIV and AIDS, a long-term study undertaken by a team from the Research Institute of the McGill University Health Centre (RI-MUHC) in collaboration with Montreal clinics and university health centres, has revealed. Researchers observed HIV-infected persons who count on social assistance and other income security programs in Quebec do not have early access to ART due to their presumed lower socio-economic status.
An international team focused on HIV cure research spearheaded by The Wistar Institute in collaboration with the University of Pennsylvania and Vall d'Hebron Research Institute (VHIR) in Barcelona, Spain, established that the CD32 molecule is not a preferential biomarker to identify HIV silent reservoirs within the immune system of patients undergoing antiretroviral therapy (ART), as proposed by a recent landmark study.
HIV uses our own cellular machinery to disable a signalling pathway (an assembly line of molecules) that produces anti-viral weaponry in the body. The scientists behind the discovery believe It should open the door to a new era of HIV research aiming to cure and eradicate this deadly virus.
Spending on HIV/AIDS globally between 2000 and 2015 totaled more than half a trillion dollars, according to a new scientific study, the first comprehensive analysis of funding for the disease.
Scientists at the University of Waterloo have developed a new tool to protect women from HIV infection.
Two genetically modified broadly neutralizing antibodies (bNAbs) protected rhesus macaques from an HIV-like virus, report scientists at the National Institute of Allergy and Infectious Diseases (NIAID). After introducing genetic mutations into two potent HIV bNAbs, researchers prepared intravenous infusions of two bNAbs. Single infusions of each modified bNAb protected monkeys against weekly exposures to simian-human immunodeficiency virus (SHIV) up to 37 weeks, compared with a median of three weeks in 12 monkeys receiving no antibody.
The 'bad apples' of the immune system are also its secret weapon, according to major Australian research published today in the world-leading journal Science. In a world first, scientists from Sydney's Garvan Institute of Medical Research have revealed how a population of 'bad' antibodies in the immune system -- which are usually 'silenced' because they can harm the body -- can provide crucial protection against invading microbes.